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Scientific reviews are now of two complementary types: short, very up-to-date articles, as are found in the Trends series, and the more traditional longer re views, which are more comprehensive but take longer to publish. The Subcellu lar Biochemistry series belongs to the latter category where a number of reviews on a broad topic are collected together in the one volume. It has been the aim of this volume to summarize the present state of knowledge of membrane assembly. It is appreciated that some relevant topics have not been included, and an editor's selection is restricted by the many calls on potential authors who are unable to meet all requests made to them. The absence of a discussion of the roles of lipids is," however, a reflection of the fact that a recent volume in this series, edited by Dr. H. 1. Hilderson, has been devoted to this subject (Vol. 16, Intracellular Transfer of Lipid Molecules), and readers are recommended to this source.
Sommario
1 Signals for Protein Targeting into and across Membranes.- 1. Introduction.- 2. Signals in the Secretory Pathway.- 3. Signals for Mitochondrial Protein Import.- 4. Signals for Chloroplast Protein Import.- 5. Signals for Nuclear Protein Import.- 6. Signals for Peroxisomal Import.- 7. Signals for Membrane Protein Assembly.- 8. Conclusions.- 9. References.- 2 Insertion of Proteins into Membranes: A Survey.- 1. Introduction.- 2. Structure of Membrane Proteins.- 3. Folding of Integral Membrane Proteins.- 4. Transmembrane Topology.- 5. Mechanisms of Insertion of Membrane Proteins.- 6. Membrane Insertion of Toxins.- 7. Conclusions.- 8. References.- 3 The Major Glycosylation Pathways of Mammalian Membranes: A Summary.- 1. Introduction.- 2. The ER-Golgi-Plasmalemma Pathway.- 3. Nuclear and Cytoplasmic Glycosylation.- 4. References.- 4 Compartments of the Early Secretory Pathway.- 1. Introduction.- 2. Compartments.- 3. Endoplasmic Reticulum.- 4. Intermediate Compartments.- 5. Conclusions.- 6. References.- 5 Assembly of Mitochondrial Membranes.- 1. Introduction.- 2. Synthesis and Targeting of Nuclear-Encoded Mitochondrial Proteins: The General Targeting Pathway.- 3. Assembly of Proteins into the Mitochondrial Outer Membrane.- 4. Assembly of Proteins in the Mitochondrial Inner Membrane.- 5. Lipid Synthesis and Localization.- 6. Conclusions.- 7. References.- 6 The Assembly of Chloroplast Membranes.- 1. Introduction.- 2. Chloroplast Structure and Biogenesis.- 3. Transport of Proteins into the Stroma.- 4. The Import and Sorting of Thylakoid Proteins.- 5. Transport of Proteins into the Chloroplast Envelope.- 6. Summary.- 7. References.- 7 Biogenesis of the Lysosomal Membrane.- 1. Introduction.- 2. Mannose Phosphate Receptors.- 3. Isolation of Lysosomal Membrane Glycoproteins.- 4. Roles of Cytoplasmic Tails in Intracellular Traffic.- 5. Cell Surface Expression of Lysosome Membrane Glycoproteins.- 6. Roles of Carbohydrates in Lamp Molecules.- 7. References.- 8 Assembly of the Peroxisomal Membranes.- 1. Introduction.- 2. Composition and Function of the Peroxisomal Membrane.- 3. Assembly of the Peroxisomal Membrane.- 4. References.- 9 Nuclear Envelope Assembly and Disassembly.- 1. Introduction.- 2. Nuclear Envelope Assembly.- 3. Nuclear Envelope Disassembly.- 4. Conclusions.- 5. References.- 10 Membrane Assembly in Bacteria.- 1. Introduction.- 2. Protein Integration into the Membranes of Escherichia coli.- 3. Protein Integration into the Membranes of ?-Purple Bacteria.- 4. References.- 11 Ischemic Effects on the Structure and Function of the Plasma Membrane.- 1. Plasma Membrane: Structure and Function.- 2. Ischemia and the Alterations of the Plasma Membrane.- 3. Conclusions.- 4. References.
