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In this book, outstanding researchers from the US and Japan review recent progress in Epstein-Barr virus research. Most people carry EBV in memory B-cells in a latent stage. Many malignancies such as T/NK cell lymphoma, AIDS-associated B-cell lymphoma, gastric carcinoma and Hodgkin's disease have been causally linked to EBV. The development of molecular biology technique has allowed us to study the roles of individual EBV genes that act in the maintenance and disruption of EBV latency.
Sommario
List of Contents.- I Molecular Mechanisms of Maintenance and Disruption of Virus Latency.- EBV's Plasmid Replicon: An Enigma in cis and trans.- Replication Licensing of the EBV oriP Minichromosome.- Epstein-Barr Virus Nuclear Protein 2-Induced Activation of the EBV-Replicative Cycle in Akata Cells: Analysis by Tetracycline-Regulated Expression.- Two Epstein-Barr Virus Glycoprotein Complexes.- EBV Replication Enzymes.- II EBV-Associated Malignancies.- Pathology and Molecular Pathology of Epstein-Barr Virus-Associated Gastric Carcinoma.- EBV and Malignant Lymphoma with Special Emphasis on Pyothorax-Associated Lymphoma.- AIDS Lymphoma: Its Virological Aspects.- III Molecular Mechanisms of Oncogenesis.- Role of Epstein-Barr Virus in Burkitt's Lymphoma.- EBV Regulates c-MYC, Apoptosis, and Tumorigenicity in Burkitt's Lymphoma.- Epstein-Barr Virus Infection of Human Epithelial Cells.- Characterization of EBV-Infected Epithelial Cell Lines from Gastric Cancer-Bearing Tissues.- IV Animal Model and New Therapeutic Approach to Malignancy.- A New Animal Model for Epstein-Barr Virus Pathogenesis.- Adoptive Immunotherapy of EBV-Associated Malignancies with EBV-Specific Cytotoxic T-Cell Lines.
Riassunto
Epstein-Barr virus (EBV) , a human herpesvirus, originally received much attention because of its associations with Burkitt's lymphoma and nasopharyngeal carcinoma. EBV is ubiquiteous in the human population and most people carry the virus in memory B-cells in a latent stage. In this book, outstandig researchers from the US and Japan review recent progress in EBV research.
