Marine Microbiology - Bioactive Compounds and Biotechnological Applications

Deliberately breaking with the classical biology-centered description of marine organisms and their products, this reference emphasizes microbial technology over basic biology, setting it apart from its predecessors. As such, it systematically covers the technology behind high-value compounds for use as pharmaceuticals, nutraceuticals or cosmetics, from prospecting to production issues.Following a definition of the field, the book goes on to address all industrially important aspects of marine microbial biotechnology. The first main part contains a description of the major production organisms, from archaebacteria to cyanobacteria to algae and symbionts, including their genetic engineering. The remaining four parts look at commercially important compounds produced by these microorganisms together with their applications. Throughout, the emphasis is on technological considerations, and the future potential of these organisms or compound classes is discussed. A valuable and forward-looking resource for innovative biotechnologists in industry as well as in academia.

Sommario

PREFACE INTRODUCTION TO MARINE ACTINOBACTERIAIntroductionActinobacteria Origin and Distribution of Marine Actinobacteria Isolation and Identification of Marine Actinobacteria Indigenous Marine Actinobacteria Role of Actinobacteria in the Marine EnvironmentImportance of Marine Actinobacteria Symbioses Bioinformatics Conclusions TREASURE HUNTING FOR USEFUL MICROORGANISMS IN THE MARINE ENVIRONMENT Introduction Microorganisms Living in the Marine EnvironmentMicroorganisms Living in Deep Sea Water STRATEGY OF MARINE VIRUSES IN GLOBAL ECOSYSTEMIntroduction Reproductive Strategies of Viruses Abundance of Marine VirusesViral Activities in Ecosystems Recent Advancement of Viruses versus Diseases The Effect of Ocean Acidification on Marine Viruses Further AspectsTAXONOMIC STUDY OF ANTIBIOTIC-PRODUCING MARINE ACTINOBACTERIA Introduction Materials and Methods Result Discussion Conclusion MARINE CYANOBACTERIA: A PROLIFIC SOURCE OF BIOACTIVE NATURAL PRODUCTS AS DRUG LEADS Introduction Bioactive Secondary Metabolites from Marine CyanobacteriaConclusions MARINE BACTERIA ARE AN ATTRACTIVE SOURCE TO OVERCOME THE PROBLEMS OF ANTIBIOTIC-RESISTANT STAPHYLOCOCCUS AUREUSIntroduction Strategies for Overcoming Antibiotic Resistance of Bacteria Marine Bacteria Are Attractive Natural Sources for Overcoming Antibiotic Resistance of MRSA MARINE BACTERIA AS PROBIOTICS AND THEIR APPLICATIONS IN AQUACULTURE Introduction Definition of Probiotics in Aquaculture Selecting and Developing Probiotics in Aquaculture Effects of Probiotics on Aquatic Organisms Probiotics in the Larviculture 1Problems Associated with Probiotics Development Further Work and Conclusions SMALL-MOLECULE ANTIBIOTICS FROM MARINE BACTERIA AND STRATEGIES TO PREVENT REDISCOVERY OF KNOWN COMPOUNDS Antibiotic Activity of Marine Bacteria Structurally Elucidated Marine Bacterial Antibiotics Cosmopolitan Antibiotics: the Rediscovery Problem Future Strategies for the Discovery of Marine Bacterial Antibiotics Conclusions and Perspectives MARINE BACTERIOPHAGES FOR THE BIOCONTROL OF FISH AND SHELLFISH DISEASESIntroduction Mode of Action of Phages Diversity of Marine Phages Application of Marine Phages to Control Fish and Shellfish Diseases Potentials and Limitations of Phage Therapy in Marine Fish and Shellfish MARINE ACTINOMYCETES AS SOURCE OF PHARMACEUTICALLY IMPORTANT COMPOUNDS Introduction Marine Actinomycetes as Source of Therapeutics Marine Actinomycete Compounds as Antibacterials Marine Actinomycete Compounds as Antitumors/Antiproliferative Marine Actinomycete Enzymes as Antiproliferatives Marine Actinomycete Compounds as Antimalarials Marine Actinomycete Compounds as Antifungals Bioactive Compounds from Sponge-Associated Actinomycetes Conclusion ANTIMICROBIAL AGENTS FROM MARINE CYANOBACTERIA AND ACTINOMYCETES Introduction Antimicrobials from Marine Actinomycetes Antimicrobials from Marine CyanobacteriaCurrent Research Status: Challenges and Future Prospects Conclusions BIOACTIVE COMPOUNDS FROM MARINE ACTINOMYCETES IntroductionActinomycetes Diversity and Distribution of Marine Actinobacteria Bioactive Compounds Conclusions FUNGAL BIOACTIVE GENE CLUSTERS: A MOLECULAR INSIGHT Introduction to Fungal Secondary Metabolites Polyketide Synthase Nonribosomal Peptide Synthetase PKS and NRPS Products Conclusions ANTICANCER POTENTIALS OF MARINE-DERIVED FUNGAL METABOLITES Introduction Marine Fungi Cancer: Initiation, Progression, and Therapeutics Anticancer Metabolites of Marine Fungal OriginFuture Prospects and Concluding RemarksANTIFUNGAL AND ANTIMYCOTOXIN ACTIVITIES OF MARINE ACTINOMYCETES AND THEIR COMPOUNDS Introduction Diversity of Actinomycetes in the Sea Diversity of Natural Compounds from Marine ActinomycetesBiological ActivitiesConclusions ANTITUBERCULOSIS MATERIALS FROM MARINE MICROBES Introduction Marine Microbe-Derived Antituberculosis Agents Conclusions HARNESSING THE CHEMICAL AND GENETIC DIVERSITIES OF MARINE MICROORGANISMS FOR MEDICAL APPLICATIONSIntroductionNovel MNPs Gene-Based Studies of MNPs MNPs Discovery Using Genome Mining Conclusion and Prospects MARINE SYMBIOTIC MICROORGANISMS: A NEW DIMENSION IN NATURAL PRODUCT RESEARCHIntroduction Marine Microorganisms and Their Symbiotic Relationships Biologically Active Metabolites of Marine Symbiotic Microbes Concluding Remarks APPLICATION OF PROBIOTICS FROM MARINE MICROBES FOR SUSTAINABLE MARINE AQUACULTURE DEVELOPMENTIntroductionThe Application of Probiotics for Marine Fishes The Application of Probiotics for Marine Crustaceans The Application of Probiotics for Marine Mollusks ANTIMICROBIAL PROPERTIES OF EICOSAPENTAENOIC ACID (C20 : 5N_3)IntroductionSpectrum of Antimicrobial Activity and Potency Structure Relationship with Activity Mechanism of Antimicrobial Action Safety, Delivery, and Biotechnological Application Concluding Remarks BIOPROSPECTING OF MARINE MICROBIAL SYMBIONTS: EXPLOITATION OF UNDEREXPLORED MARINE MICROORGANISMS Introduction Marine Microbial SymbiontsBioethical and Supply Issues in Utilizing Marine InvertebratesMarine Fungal Symbionts of Corals as Sustainable Sources of Marine Natural ProductsMarine Actinomycete Symbionts as Prolific Marine Natural Products New Avenue of Research: Marine Natural Products from Fungal Symbionts of CoralsConcluding Remarks MARINE MICROORGANISMS AND THEIR VERSATILE APPLICATIONS IN BIOACTIVE COMPOUNDS IntroductionSeparation and Isolation Techniques of Bioactive Compounds from Marine Organisms Different Bioactive Compounds from Marine OrganismsPolysaccharides Pigments Conclusions METABOLITES OF MARINE MICROORGANISMS AND THEIR PHARMACOLOGICAL ACTIVITIES IntroductionMarine Fungi Marine Actinomycetes Marine CyanobacteriaConclusions SPONGES: A RESERVOIR FOR MICROORGANISM-DERIVED BIOACTIVE METABOLITES Introduction Collection of Sponges and Associated Microbes Bacteria Unidentified Bacteria Fungi Unidentified Fungal Strains from Sponges Compounds in Clinical Trial and Use ConclusionsBIOACTIVE MARINE MICROORGANISMS FOR BIOCATALYTIC REACTIONS IN ORGANIC COMPOUNDSIntroduction Marine EnzymesBiotransformation of Natural Products by Marine BiocatalystsBiodegradation of Organic Compounds by Marine Biocatalysts Reduction of Carbonyl Groups (Ketones and Keto Esters) by Marine Biocatalysts Hydrolysis of Epoxides by Marine Biocatalysts Collection and Isolation of Bioactive Marine Microorganisms Conclusions and Perspectives MARINE MICROBIAL ENZYMES: BIOTECHNOLOGICAL AND BIOMEDICAL ASPECTS Introduction Extremozymes: Most Potential Marine Enzymes Biotechnological Aspects Biomedical Aspects Concluding Remarks and Perspectives BIOMEDICAL APPLICATIONS OF MYCOSPORINE-LIKE AMINO ACIDS IntroductionMycosporine-Like Amino Acids (MAAs)Distribution of MAAsGenetic Control of MAAs Synthesis MAAs InductionBiomedical Potentials of MAAs MAAs as PhotoprotectantsMAAs as an Antioxidant MAAs as Blocker of Dimer Formation MAAs as an Osmoregulator Conclusions and Future Prospects INDEX

Info autore

Se-Kwon Kim is Professor of Marine Biochemistry at Pukyong National University in Busan, South Korea. A graduate of PKNU, he conducted his postdoctoral studies at the University of Illinois (USA), and was a visiting scientist at the Memorial University of Newfoundland (Canada). His major research interests are the investigation and development of bioactive substances derived from marine organisms and their application as cosmeceuticals and nutraceuticals. Professor Kim is the current editor-in-chief of the Korean Journal of Marine Bioscience and Biotechnology. He has authored over 450 research papers, holds 72 patents, and has written or edited more than 30 books.

Riassunto

Deliberately breaking with the classical biology-centered description of marine organisms and their products, this reference emphasizes microbial technology over basic biology, setting it apart from its predecessors. As such, it systematically covers the technology behind high-value compounds for use as pharmaceuticals, nutraceuticals or cosmetics, from prospecting to production issues.

Following a definition of the field, the book goes on to address all industrially important aspects of marine microbial biotechnology. The first main part contains a description of the major production organisms, from archaebacteria to cyanobacteria to algae and symbionts, including their genetic engineering. The remaining four parts look at commercially important compounds produced by these microorganisms together with their applications. Throughout, the emphasis is on technological considerations, and the future potential of these organisms or compound classes is discussed. A valuable and forward-looking resource for innovative biotechnologists in industry as well as in academia.

Dettagli sul prodotto

• Autori: Se-Kwon Kim
• Con la collaborazione di: Se-Kwo Kim (Editore), Se-Kwon Kim (Editore)
• Editore: Wiley-VCH
• Lingue: Inglese
• Formato: Copertina rigida
• Pubblicazione: 14.08.2013
• EAN: 9783527333271
• ISBN: 978-3-527-33327-1
• Pagine: 580
• Dimensioni: 174 mm x 249 mm x 33 mm
• Peso: 1372 g
• Illustrazioni: 68 SW-Abb., 49 Tabellen
• Categorie: Scienze naturali, medicina, informatica, tecnica > Chimica; Chemie, Biotechnologie, Mikrobiologie, Meeresbiologie, Life Sciences, Biowissenschaften, biotechnology, chemistry, Biotechnologie i. d. Biowissenschaften, Pharmaceutical & Medicinal Chemistry, Pharmazeutische u. Medizinische Chemie, Biotechnologie i. d. Chemie, Bioaktive Verbindungen