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Informationen zum Autor Lorenzo A. Pinna received his B. Sc. in Biochemistry from the University of Padova in 1962. From 1965-66 he was postdoctoral fellow at the Department of Physiological Chemistry, Johns Hopkins University Medical School, Baltimore, USA. In 1975 he was appointed Professor of Medical Chemistry and Biochemistry and in 1988 Director of the Department of Biological Chemistry at the University of Padova. A pioneer in the field of CK2 research, his research interests encompass various aspects of protein phosphorylation, with special reference to the design of synthetic peptide substrates for the specific monitoring of protein kinases and the assessment of the biological role and pathogenic potential of protein kinase CK2. Klappentext The importance of CK2 in cancer and other diseases has generated a significant amount of literature on the protein, and an international community of CK2 researchers. The International Union of Biochemistry and Molecular Biology (IUMBMB) sponsors periodic international conferences on CK2, making the protein a natural topic for a Wiley-IUBMB publication.Protein Kinase CK2 will deal with structural aspects underlying the constitutive activity of CK2, its specific susceptibility to pharmacological inhibition and its extraordinary pleiotropy. In the second part the fundamental role of CK2 in a wide number of biological functions will be illustrated, while the third part will be devoted to the unusual mode of implication of CK2 in neoplastic transformation, with an appendix reviewing its potential relevance to other pathologies. Zusammenfassung * Explores the role of CK2 as a target in cancer treatment * Written by an international group of experts in the field * Covers the molecular, structural and functional aspects of CK2 * Includes appendix with information on the implication of CK2 in non-oncologic diseases . Inhaltsverzeichnis Contributors xi Preface xv Part 1 Molecular and Structural Aspects 1 1 Structural Bases of Protein Kinase CK2 Function and Inhibition 3 Karsten Niefind and Roberto Battistutta Introduction 3 Basic Structure/Function Relationships of CK2 8 CK2 Inhibitors 37 Conclusions and Outlook 60 Acknowledgments 61 2 The Interactome of Protein Kinase CK2 76 Mathias Montenarh and Claudia Götz Introduction 76 From the Outside to the Inside: Interaction of CK2 with Membrane Proteins 78 Regulating Gene Expression: Interaction of CK2 with Components of Signaling Cascades, Transcription Factors and DNA Modifying Enzymes 82 Mastering Nucleic Acid Functions: Interaction of CK2 with Proteins of the Replication, Transcription, and Translation Machinery of the Cell 87 Let It Roll: Interaction of CK2 with Cell Cycle Regulatory Proteins 90 Guardian Angels: Interaction of CK2 with Proteins That Maintain the Cellular Integrity 93 Live and Let Die: Interaction of CK2 with Proteins of the Apoptotic Pathway 96 Highways in the Cell: Interaction of CK2 with the Cytoskeleton and Motor Proteins 96 Collaborating with the Enemy: Interaction of CK2 with Proteins Implicated in Viral Infections 98 Last But Not Least: Miscellaneous 99 Concluding Remarks 101 3 CK2 Contribution to the Generation of the Human Phosphoproteome 117 Luca Cesaro and Mauro Salvi Kinases Contribution to the Human Phosphoproteome 117 CK2 Substrate Specificity 118 Subphosphoproteomes of Proteins with Specific Functions 122 Subphosphoproteomes of Cellular Compartments 123 Absolute Quantification of Yeast Phosphoproteome Reflects the Constitutive Activity of CK2 125 Conclusions 125 Acknowledgments 126 Part 2 Functional Aspects 129 4 CK2 in Embryonic Development 131 Laura Macias Alva...
