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Informationen zum Autor Edited by Adam P. Fraise, Queen Elizabeth Medical Centre, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK Jean-Yves Maillard, Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, UK Syed A. Sattar, Centre for Research in Environmental Microbiology, University of Ottawa, Ottawa, Canada Klappentext Russell, Hugo & Ayliffe's Principles and Practice of Disinfection, Preservation and Sterilization The new edition of this established and highly respected text is THE definitive reference in its field. It details methods for the elimination or prevention/control of microbial growth, and features: New chapters on bioterrorism and community healthcare New chapters on microbicide regulations in the EU, USA and Canada Latest material on microbial resistance to microbicides Updated material on new and emerging technologies, focusing on special problems in hospitals, dentistry and pharmaceutical practice Practical advice on problems of disinfection and antiseptics in healthcare A systematic review of sterilization methods, with uses and advantages outlined for each Evaluation of disinfectants and their mechanisms of action with respect to current regulations The differences between European and North American regulations are highlighted throughout, making this a truly global work, ideal for worldwide healthcare professionals working in infectious diseases and infection control Zusammenfassung The new edition of this established and highly respected text is THE definitive reference in its field. Inhaltsverzeichnis List of Contributors vii Preface to the Fifth Edition x Preface to the First Edition xi Section 1 Principles 1 Historical Introduction 1 Adam P. Fraise 2 Types of Microbicidal and Microbistatic Agents 5 Ibrahim Al-Adham Randa Haddadin and Phillip Collier 3 Factors Affecting the Activities of Microbicides 71 Jean-Yves Maillard 4 Biofilm Recalcitrance: Theories and Mechanisms 87 Andrew J. McBain Najib Sufya and Alexander H. Rickard 5 Mechanisms of Action of Microbicides 95 Peter A. Lambert 6 Bacterial Sensitivity and Resistance to Microbicides 108 6.1 Mechanisms of Bacterial Resistance to Microbicides 108 Jean-Yves Maillard 6.2 Resistance of Bacterial Spores to Chemical Agents 121 Peter Setlow 6.3 Testing of Chemicals as Mycobactericidal Agents 131 Syed A. Sattar 7 Fungicidal Activity of Microbicides 142 Sara Fernandes Marta Simões Nicolina Dias Cledir Santos and Nelson Lima 8 Sensitivity and Resistance of Protozoa to Microbicides 155 Vincent Thomas 9 Virucidal Activity of Microbicides 178 Jean-Yves Maillard Syed A. Sattar and Federica Pinto 10 Transmissible Spongiform Encephalopathies and Decontamination 208 Gerald McDonnell 11 Microbicides - the Double-edged Sword: Environmental Toxicity and Emerging Resistance 229 Jean-Marie Pagès Jean-Yves Maillard Anne Davin-Regli and Susan Springthorpe Section 2 Practice 12 Evaluation of Antimicrobial Efficacy 236 Lawrence Staniforth 13 Assessing the Efficacy of Professional Healthcare Antiseptics: a Regulatory Perspective 247 Albert T. Sheldon 14 Regulation of Microbicides 255 14.1 Legislation Affecting Disinfectant Products in Europe: the Biocidal Products Directive and the Registration Evaluation and Authorization of Chemicals Regulations 255 Jennifer A. Hopkins 14.2 Regulatory Authorization of Hard Surface Disinfectants in Canada 262 Andre G. Craan Ian A. Chisholm and Shannon C. Wright 14.3 United States Regulation of Antimicro...
