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0 Behavioral Reaction Effect of Effect of Species Route of Dose of Reference - 0 oxytocin vasopressin treatment oxytocin (mol/animal) p r-' 11 Extinction of active avoidance Facilitation Opposite Rat i. p. 2x 10- SCHULZ et al. (1974, 1976); ~ (bench-jumping) reaction TELEGDY and KovAcs (1979a) 0 12 10- Extinction of active avoidance Facilitation Opposite Rat i. c. v. BOHUS et aI. (1978b) "', 0 (pole-jumping) reaction '" 10 2 x 10- Extinction of active avoidance Delay Similar Rat s. c. WALTER et aI. (1978); (pole-jumping) behavior BoHUS et al. (1978b) 12 10- Acquisition of active avoidance Delay No effect Rat i. c. v. BoHUS et al. (1978b) (pole-jumping) behavior 11 2x 10- Acquisition of active avoidance No effect No effect Rat i. p. SCHULZ et al. (1974) (bench-jumping) behavior 10 Passive avoidance (step-down) Attenuation Opposite Rat i. p. 2x 10- KovAcs et al. (1978) behavior 13 10- Passive avoidance (step-through) Attenuation Opposite Rat i. c. v. BoHUS et al. (1978a, b); behavior KovAcs and DE WmD (1983) 14 2. 5 x 10- Passive avoidance (step-through) Attenuation Opposite Rat Hippocampus, KovAcs et al. (1979) behavior dorsal raphe 14 Passive avoidance (step-through) Facilitation Similar Rat Septum 2. 5 x 10- KovAcs et al. (1979) behavior 8 10- Passive avoidance (choice No effect No effect Rat ? SAGHAL and WRIGHT (1984) measure) 7 Attenuation of puromycin- 10- No effect Effective Mouse s. c WALTER et al.
Sommario
Biosynthesis of Oxytocin in the Brain and Peripheral Organs.- Regulation of Oxytocin Release.- Proteolytic Conversion of Oxytocin, Vasopressin, and Related Peptides in the Brain.- Oxytocin and Behavior.- Oxytocin as an Ovarian Hormone.- Oxytocin and the Milk-Ejection Reflex.
Info autore
Detlev Ganten, geb. 1941, zählt zu den herausragenden Persönlichkeiten in der europäischen Forschungslandschaft. Er ist u.a. Gründungsdirektor des Max-Delbrück-Centrums für molekulare Medizin, Professor für Klinische Pharmakologie an der FU Berlin, Mitglied im Nationalen Ethikrat und Vizepräsident der Berlin-Brandenburgischen Akademie der Wissenschaften.
J. Peter H. Burbach is professor of Molecular Neuroscience at Utrecht University and head of the Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands. His research interests concern the role of transcription factors in development and regulation of peptidergic and dopaminergic neurons, and the molecular mechanisms of human neurodevelopmental disorders. He received his PhD from Utrecht University and did postdoctoral work at the Clinical Research Institute of Montreal, Canada. He obtained professorships in Molecular Biology and Molecular Neuroendocrinology.
