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Provided here is an easily accessible introduction to themechanisms of DNA replication, regulation and thebiochemistry of cell cycle control. An overview of thisrapidly developing field is presented to orient the reader,followed by a series of contributions by leading researcherssummarizing recent results on selected topics, such asprotein phosporylation, tumor suppressor genes, and signaltransduction in prokaryotic and eucaryotic systems. Thereader will gain an overview of our current understanding ofDNA replication and the cell cycle, and a selection ofuseful recent references for further reading.
Sommario
Introductory Remarks. The Initiation ofEukaryotic DNA Replication and Its Control.- Regulation of DNA Replication in Model Systems.- Regulation of DNA Replication in Escherichia coli.- Protein-Primed Replication of Bacteriophage ø29 DNA.- Initiation of Bacteriophage ? DNA Replication in Vitro in a System Reconstituted with Purified Proteins.- Mechanisms Controlling Hepadnaviral Nucleocapsid Assembly and Replication.- Basic Elements of the Eukaryotic Replication Process.- Mammalian DNA Helicases, DNA Polymerases and DNA Polymerase Auxiliary Proteins.- Protein-DNA Interaction at Yeast Replication Origins: An Ars Consensus Binding Protein.- Eukaryotic Origins of DNA Replication.- Protein-Induced Alterations in DNA Structure at the dhfr Origin of Replication.- Mechanism and Control of Cellular DNA Replication.- Protein Kinases and Replication Control.- Regulation of the Mitotic CDC2 Protein Kinase.- Control of SV 40 DNA Replication by Protein Phosphorylation.- The Mitogen/Oncogene-Activated p70s6k: Its Role in the G0/G1 Transition.- Ubiquitin-Dependent Protein Degradation.- Transcriptional Control of Cell Proliferation.- Ternary Complex Formation at the Human cfos Serum Response Element.- Function and Regulation of DNA Replication Genes in Budding Yeast An Overview.- Functional Analysis of Recombinant mUBF, a Murine rDNA Transcription Initiation Factor Which is Phosphorylated by Casein Kinase II.- Antisense Strategies for Modulating the Repression of Cell Division.- Growth Suppressors and the Decision to Replicate the Genome.- Biological Phenotypes of Tumor-Derived Human p53 Mutants.- Association of Wild Type P-53 with Cell Differentiation: Induction of Pre-b Cell Maturation in Vitro.- The Growing Biological Scenario of Growth Arrest.
Info autore
Rolf Knippers hat von 1955-62 Medizin studiert und sich danach der Molekularbiologie zugewandt. Nach Lehrjahren am Max-Planck-Institut für Medizinische Forschung, Heidelberg, hat er mehrere Jahre lang am renommierten California Institute of Technology, Pasadena, gearbeitet. Seit 1973 bis zu seiner Emeritierung im Jahre 2004 war Rolf Knippers Professor für Molekulare Genetik an der Universität Konstanz. Er hat in zahlreichen nationalen und internationalen Wissenschaftsgremien und Beiräten mitgewirkt und wurde zum Mitglied der Europäischen Molekularbiologie-Organisation (EMBO) gewählt.
