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The rapid development and recent advances in this field seemed to justify a further meeting dealing primarily with protein interconversions and their biological significance rather soon after the first symposium of this kind, held under the direction of Professor G. BONSIGNORE of Genoa, in Santa Margherita Ligure, Italy, in May 1970. The proceedings of the Second International Symposium on Metabolic Interconversion of Enzymes, held in Rottach-Egern, in the Bavarian Alps, from October 27-30, 1971, under the auspices of the "Gesellschaft Deutscher N aturforscher und Arzte" bear witness to the high quality of the research reports and the lively discussions which ensued. There are contributions by a number of distinguished scientists and experts in the field who came from several European countries, Canada, Israel, Japan, the Soviet Union and the United States in order to participate in this symposium. We wish to express our sincere gratitude to the speakers for all their efforts. The main burden of the editorial work was carried by Dr. G. LOFFLER, Munich, ably as Dr. A. R. FERGUSON, Freiburg, Dr. R. H. HASCHKE, Wiirzburg, Dr. A. HASILlK, sisted by Freiburg, Dr. L. HEILMEYER Jr. , Wiirzburg, Dr. E. SIESS, Munich, and by the secretaries, Miss E. BAUER, Munich and Mrs. G. WEIDEMANN, Wiirzburg. To the publishers, Springer Verlag Berlin Heidelberg New York, and especially to Dr. H. MAYER-KAUPP, we are greatly indebted for their cooperation.
Sommario
Welcoming Remarks.- Metabolic Interconversion of Enzymes: Introductory Remarks.- Comparative and Evolutionary Aspects of the Control of Phosphorylase.- Electron Microscopy of Muscle Phosphorylases b and a.- Discussion.- Studies on Glycogen Phosphorylase in Solution and in the Crystalline State.- Probing and Mapping the Pyridoxal 5?-Phosphate Site of Glycogen Phosphorylase.- Association-dissociation Properties of NaBH4-reduced Phosphorylase b.- The Mechanism of Action of Cyclic AMP in the Activation of Phosphorylase Kinase.- Discussion.- Phosphorylase a as a Glucose Receptor.- Properties of Purified Glycogen Synthetase b from Liver.- Discussion.- The Mechanism of Activation of the Lac Operon.- Discussion.- Regulatory Mechanism of Enzyme Catabolism.- Discussion.- Interconversion of Two Forms of Leucyl-tRNA Synthetase.- Discussion.- Diphtheria Toxin-catalyzed Adenosine Diphosphoribosylation of Aminoacyl Transferase II from Rat Liver.- Discussion.- Regulation of Transcription by T4 Phage Induced Chemical Alteration and Modification of Transcriptase (EC2.7.7.6).- Discussion.- On the Mechanism of Action and Metabolic Control of the Multifunctional Enzyme Complex that Catalyzes Adenylylation and Deadenylylation of Escherichia Coli Glutamine Synthetase.- Inactivation of Glutamine Synthetase in Intact E. coli Cells.- Studies on the Mechanism of the ATP: Glutamine Synthetase Adenylyltransferase Reaction.- The Role of Enzyme Inactivation in the Regulation of Glutamine Synthesis in Yeast: in vivo Studies Using 15NH3.- Discussion.- Molecular Aspects of the Regulation of the Mammalian Pyruvate Dehydrogenase Complex.- Regulation of the Mammalian Pyruvate Dehydrogenase Complex: Physiological Aspects and Characterization of PDH-Phosphatase from Pig Heart.- Discussion.-Enzyme-dependent Activation of P ruvate Formate-lyase of, Escherichia coli.- Discussion.- Lactose Synthetase: Structure and Function.- UDP-glucose: D-fructose-6-phosphate 2-glucosyltransferase: Metabolic Control of the Enzyme Activity.- Discussion.- Mechanism of Interaction between Arginase and Ornithine Transcarbamoyl Transferase of Saccharomyces cerevisiae.- Discussion.- Enzymatic Modification of Basic Chromosomal Proteins in Developing Trout Testis.- Discussion.- Active Site-directed Side Chain Modification.- Discussion.- Metabolic Interconversion: of Enzymes: Relation to the Hysteretic Response.- Discussion.- Why Are Enzymes Interconvertible?.- General Discussion.- List of Participants.
