Ulteriori informazioni
In 1976, when Springer-Verlag commissioned Professors Giebisch, Tosteson, and Ussing to edit what was destined to become a monumental five-volume Handbuch (" Membrane Transport in Biology", 1978 [Vols I, II, III] and 1979 [Vols IV A, B]), the subject of transepithelial secretion was still in its infancy. Not surprisingly, therefore, their Handbuch concentrated mainly on trans epithelial absorption, although substantial chapters dealing with some secre viz. "Ion Transport Across the Choroid Plexus" tory organs were included, (by E. M. Wright), "Sweat Glands" (by J. H. Thaysen), "Lacrimal Gland" (by J. H. Thaysen) and "Transport Across Insect Excretory Epithelia" (by J. P. H. Maddrell) in Volume III and "Transport in Salivary and Salt Glands" (by J. A. Young and E. W. Van Lennep), "Gastric Secretion" (by T. E. Machen and J. G. Forte), "Transport Processes in the Exocrine Pan creas" (by I. Schulz and K. J. Ullrich), and "Transport of Ions in Liver Cells" (by M. Claret) in Volume IVB. The publication in 1977 of the seminal paper of Silva and his colleagues on the mechanism of secretion of salt and water in the salt excreting gland of the dogfish (American Journal of Physiology 233, F298-F306, 1977) provided physiologists with their first real insight into the mechanisms underlying transepithelial fluid secretion, however, and, in the ensuing years, interest in the topic has exploded as is evidenced by the numerous international symposia on exocrine secretion held since that date.
Sommario
A General Aspects of Secretion.- Epithelial Chloride Channels.- Cation Channels and Secretion.- Gap Junctions in Exocrine Glands.- Ion Channels in the Intracellular Organelles of Secretory Cells.- Changes in Membrane Capacitance in Exocrine Secretion.- The Coupling of Stimuli to the Secretion of Protein in Exocrine Glands.- Ion Transport in Mutant Cell Lines: Possibilities for Analysis.- Use of Nuclear Magnetic Resonance Spectroscopy in the Study of Exocrine Secretion.- Graded Modelling of Exocrine Secretion Using Network Thermodynamics.- B Secretion in Individual Tissues.- 1 Salivary Glands.- Role of Anion Transport in Secretion of Primary Saliva.- The Role of Transcellular Chloride Transport in Exocrine Secretion.- Bicarbonate Transport by Salivary Gland Acinar Cells.- Electrophysiology of Salivary Acinar Cells: Microelectrode Studies.- Physiology of Salivary Gland Exocytosis.- Non-Adrenergic, Non-Cholinergic Control of Salivary Gland Function.- 2 Lacrimal Glands.- Electrolyte Secretion by the Lacrimal Glands.- 3 Exocrine Pancreas.- Electrolyte Transport in Pancreatic Ducts.- The Role of Ion Channels in the Mechanism of Pancreatic Bicarbonate Secretion.- The Metabolic Basis of Secretion by the Exocrine Pancreas.- 4 Endocrine Pancreas.- Ion Channels in Insulin-Secreting Cells: Their Role in Stimulus-Secretion Coupling.- 5 Gastric Mucosa.- Electrophysiological Aspects of Gastric Ion Transport.- 6 Liver.- Hepatic Electrolyte Transport and Bile Formation.- 7 Epididymis.- Electrolyte and Fluid Transport in the Epididymis.- 8 Salt Glands.- Ultrastructure and X-Ray Microanalysis of Vertebrate Salt Glands.- 9 Cystic Fibrotic Epithelia.- Ion Transport Regulation in Cystic Fibrosis Epithelia.
Riassunto
This volume aims to give a comprehensive overview of the cellular mechanisms underlying the process of secretion in vertebrate, particularly mammalian, exocrine glands.
