Asymmetric Synthesis of Natural Products

Informationen zum Autor Professor Ari M.P. Koskinen, Department of Chemistry, School of Science and Technology, Aalto University, FinlandProfessor Koskinen has held academic appointments at the University of Sussex and University of Oulu , and transferred to his current position at Aalto University in 1999 as Professor of Organic Chemistry. He also holds docentships at the Universities of Helsinki and Turku. Professor Koskinen is a member of the Finnish Academy of Sciences and Letters, the Novartis Foundation International Scientific Advisory Panel, the Scientific Advisory Board of the Finnish Chemical Industry Federation, European Society for Combinatorial Sciences, on the management committees of EU-research programs, and is a founding member of the European Chemical Society. He is the author or co-author of some 160 publications, 15 patents and three books. Klappentext Asymmetric Synthesis of Natural Products, 2nd Edition introduces students to this rapidly growing field of organic chemistry. The initial chapters present the foundations of asymmetric synthesis, including the theory and applications of individual asymmetric reactions. This is followed by chapters on each of the major individual classes of natural products; their structures, biosynthesis and interrelationships as well as examples of asymmetric syntheses and the practical value of these compounds. Natural product classes covered include carbohydrates, amino acids, peptides, proteins, nucleosides, nucleotides, nucleic acids, polyketides, isoprenoids, shikamic acid derivatives and alkaloids.For this second edition the text has been thoroughly updated and expanded, and includes new discussions and examples covering atom and redox economies, practical aspects and environmental awareness. Organocatalysis has emerged completely in the last ten years, and has been fully integrated into this new edition. Zusammenfassung Asymmetric Synthesis of Natural Products, 2nd Edition introduces students to this rapidly growing field of organic chemistry. The initial chapters present the foundations of asymmetric synthesis, including the theory and applications of individual asymmetric reactions. Inhaltsverzeichnis List of Common Abbreviations ixPreface to the First Edition xiiiPreface to the Second Edition xv1 Introduction 11.1 Some properties of natural products 41.2 Natural products as drugs 71.3 Structures of natural products 101.4 Asymmetric synthesis of natural products 151.5 Synthetic organic chemistry 17References 2022 Chirality, Topology, and Asymmetric Synthesis 232.1 The need for enantiopure compounds 342.2 Determination of enantiomeric purity 382.3 Chirality and thermodynamic principles of asymmetric induction 422.4 Methods for obtaining chiral compounds 44References 5233 Asymmetric Synthesis 553.1 Allylic strain 553.2 Reactions of the carbonyl group 593.2.1 Nucleophilic additions on the carbonyl carbon 593.2.2 Reactions at the3.2.3 Reactions at the3.2.4 Reactions of olefins 993.3 Oxidation 993.3.1 Asymmetric dihydroxylation 1003.3.2 Asymmetric epoxidation 103References 1084 Sugars 1154.1 Monosaccharides 1164.1.1 Aldoses and ketoses 1164.1.2 Deoxy sugars 1224.1.3 Amino sugars 1224.1.4 Sugar alcohols 1254.1.5 Acidic sugars 1254.2 Polysaccharides 1274.3 Glycoproteins and proteoglycans 1314.4 Glycolipids 1344.5 Sugar antibiotics 1344.6 Cyclitols 138References 1425 Amino Acids, Peptides, and Proteins 1455.1 Amino acids 1455.2 Peptides and proteins 1495.3 Enzymes and receptors 1535.4 Chemical modifications of peptides 1545.5 Biosynthesis of amino acids 1565.6 Asymmetric synthesis of amino acids 1605.6.1 alpha-Alkylation 1625.6.2 Amination of ester enolates 1675.6.3 Catalytic hydrogenation 1695.6.4 Miscellaneous 1705.6.5 Pepstatins 171References 1736 Nucleosides, Nucleotides, and Nucleic Acids 175References 1847 Polyketides...

Dettagli sul prodotto

• Autori: Ari Koskinen, Ari M P Koskinen, Ari M. P. Koskinen, KOSKINEN ARI M P
• Editore: Wiley, John and Sons Ltd
• Lingue: Inglese
• Formato: Copertina rigida
• Pubblicazione: 20.07.2012
• EAN: 9781119976684
• ISBN: 978-1-119-97668-4
• Pagine: 322
• Categoria: Scienze naturali, medicina, informatica, tecnica > Chimica > Chimica organica