Oral Precancer - Diagnosis and Management of Potentially Malignant Disorders

Informationen zum Autor Peter Thomson is Professor of Oral and Maxillofacial Surgery at Newcastle University and Honorary Consultant in Oral and Maxillofacial Surgery at Newcastle upon Tyne Hospitals NHS Foundation Trust. In recognition of his research into oral cancer & precancer, he has been awarded both a Hunterian Professorship from the Royal College of Surgeons of England & a King James IV Professorship from the Royal College of Surgeons in Edinburgh. Klappentext Without early detection, oral cancer is deadly. Protect your patients by applying the latest clinical interventions.Rates of new oral cancer cases continue to increase and mortality rates remain alarmingly high. Oralcancer may be preceded by clinically identifiable precancerous changes in the oral mucosa, which offer a therapeutic window of opportunity to intervene and halt disease progression to carcinoma development.Written and edited by prominent researchers in the field, Oral Precancer:* Reviews current scientific research on precancer conditions of the oral cavity providing evidence-based analysis of the nature and behavior of potentially malignant and deforming oral diseases* Explains the principles of prevention, diagnosis and management of potentially malignant disorders of the oral cavity* Details a practical and reliable interventional treatment strategy to facilitate early diagnosis and effective treatment of both precancer and early invasive carcinoma* Contains a chapter devoted to illustrative case histories, high-quality, color, clinical photos, reference sections in each chapter listing relevant review articles, and moreFrom start to finish, Oral Precancer offers undergraduate students, clinicians, and professors an invaluable resource to minimise the morbidity and mortality of this most significant and life threatening of oral conditions. Zusammenfassung Without early detection, oral cancer is deadly. Protect your patients by applying the latest clinical interventions. Rates of new oral cancer cases continue to increase and mortality rates remain alarmingly high. Inhaltsverzeichnis List of Contributors Preface Acknowledgements 1. Introduction General Introduction Epidemiology Prevention Treatment Strategies Terminology Summary References 2. Structure and Function of Oral Mucosa Introduction Applied Anatomy of the Oral Cavity Function of the Oral Mucosa The Microanatomy of Oral Mucosa Regional Variation of Oral Mucosa Oral Epithelial Cell Kinetics Oral Epithelial Cell Proliferative Activity Anatomical Site Predilection for Oral Carcinogenesis Summary References 3. Oral Carcinogenesis Introduction Oral Cancer and Precancer The 'Progression Model' for Oral Cancer Aetiology and Risk Factors Patient and Risk Factor Profiling Summary References 4. Clinical Presentation of Oral Precancer Introduction Clinical Terminology Precancerous (Premalignant) Lesions Precancerous (Premalignant) Conditions Multiple Lesion Disease Summary References 5. Diagnostic Methods Introduction Screening Clinical Examination Techniques Vital Tissue Staining Light Based Detection Systems Brush Biopsy and Exfoliative Cytology Clinical Diagnosis in Practice Summary References 6. Pathological Aspects of Oral Precancer Introduction Biopsy Techniques The Role of the Pathologist Histopathological Features of Oral Potentially Malignant Disorders Grading of Dysplasia Limitations in Conventional Pathological Techniques Summary References 7. Management of Oral Precancer Introduction Risk Factor Modification Observation...

Sommario

List of Contributors
 
Preface
 
Acknowledgements
 
1. Introduction
 
General Introduction
 
Epidemiology
 
Prevention Treatment Strategies
 
Terminology
 
Summary
 
References
 
2. Structure and Function of Oral Mucosa
 
Introduction
 
Applied Anatomy of the Oral Cavity
 
Function of the Oral Mucosa
 
The Microanatomy of Oral Mucosa
 
Regional Variation of Oral Mucosa
 
Oral Epithelial Cell Kinetics
 
Oral Epithelial Cell Proliferative Activity
 
Anatomical Site Predilection for Oral Carcinogenesis
 
Summary
 
References
 
3. Oral Carcinogenesis
 
Introduction
 
Oral Cancer and Precancer
 
The 'Progression Model' for Oral Cancer
 
Aetiology and Risk Factors
 
Patient and Risk Factor Profiling
 
Summary
 
References
 
4. Clinical Presentation of Oral Precancer
 
Introduction
 
Clinical Terminology
 
Precancerous (Premalignant) Lesions
 
Precancerous (Premalignant) Conditions
 
Multiple Lesion Disease
 
Summary
 
References
 
5. Diagnostic Methods
 
Introduction
 
Screening
 
Clinical Examination Techniques
 
Vital Tissue Staining
 
Light Based Detection Systems
 
Brush Biopsy and Exfoliative Cytology
 
Clinical Diagnosis in Practice
 
Summary
 
References
 
6. Pathological Aspects of Oral Precancer
 
Introduction
 
Biopsy Techniques
 
The Role of the Pathologist
 
Histopathological Features of Oral Potentially Malignant Disorders
 
Grading of Dysplasia
 
Limitations in Conventional Pathological Techniques
 
Summary
 
References
 
7. Management of Oral Precancer
 
Introduction
 
Risk Factor Modification
 
Observation versus Intervention
 
Medical Treatment
 
Surgical Treatment
 
Interventional Laser Surgery
 
Combined Treatment Modalities
 
Patient Follow Up and Surveillance
 
Summary
 
References
 
8. Clinical Outcome
 
Introduction
 
Clinical Outcome Studies
 
Patient Cohort Studies
 
Definitions of Clinical Outcome
 
Newcastle Patient Cohort Studies
 
Patient Follow Up
 
Prediction of Clinical Outcome
 
Summary
 
References
 
9. Malignant Transformation and Oral Cancer Development
 
Introduction
 
The Risk of Progression to Oral Carcinoma
 
Malignant Transformation versus Oral Cancer Development
 
Interventional Laser Surgery and Oral Cancer Prevention
 
The Newcastle 10 Year Follow Up Study
 
High and Low Risk Patients
 
Clinical Signs of Oral Squamous Cell Carcinoma
 
Diagnosis and Management of 'Unexpected Malignancy'
 
Prognosis for the 'Transformed Patient'
 
Summary
 
References
 
10. The Future
 
Introduction
 
Prevention of Oral Precancer
 
Early Diagnosis of Potentially Malignant Disease
 
Interventional Management Strategies in the Future
 
Individualised Patient Treatments - Biomarkers and Targeted Chemoprevention
 
Future Research Directions
 
Summary
 
References
 
11. Case Histories
 
Introduction
 
Diagnosis of Unexpected Malignancy
 
Multiple Lesion Disease Responding to Conservative Management
 
Multiple Les

Relazione

"I would highly recommend the book for those wishing to expand their knowledge on oral malignancy at a specialist trainee or higher level." ( British Dental Journal , 12 October 2013)

Dettagli sul prodotto

• Autori: P Thomson, Peter Thomson, Peter (School of Dental Sciences Thomson
• Con la collaborazione di: Pete Thomson (Editore), Peter Thomson (Editore)
• Editore: Wiley, John and Sons Ltd
• Lingue: Inglese
• Formato: Copertina rigida
• Pubblicazione: 30.03.2012
• EAN: 9781444335743
• ISBN: 978-1-4443-3574-3
• Pagine: 236
• Categorie: Scienze naturali, medicina, informatica, tecnica > Medicina > Branche non cliniche; Zahnmedizin, dentistry, Oral Pathology, Oralpathologie, Dentistry and related oral medicines