Biomaterials for Spinal Surgery

Informationen zum Autor Professor Luigi Ambrosio is a Research Director at the Institute for Polymers, Composites and Biomaterials, Italy. He is a renowned scientist with expertise in biomedical composites and has published over 300 papers in international scientific journals and books, 16 patents, 150 invited lectures and over 400 presentations at international and national conferences. Elizabeth Tanner is Professor of Mechanics of Materials and Structures at the University of Glasgow, UK. Both are noted for their research in bone biomaterials and therapies. Klappentext A review of spine biology and biomechanics! the latest developments in spinal biomaterials such as cages! plates and discs! and developments in regeneration of the spine. Chapters include biomechanics on the spine! disc replacement! vertebroplasty and scoliosis surgery. Zusammenfassung There have been important developments in materials and therapies for the treatment of spinal conditions. Biomaterials for spinal surgery summarises this research and how it is being applied for the benefit of patients. Inhaltsverzeichnis Contributor contact details Chapter 1: Introduction to biomaterials for spinal surgery Abstract: 1.1 Introduction 1.2 Total disc replacement 1.3 Nucleus pulposus replacement 1.4 Materials for spinal applications 1.5 Conclusions Part I: Fundamentals of biomaterials for spinal surgery Chapter 2: An overview of the challenges of bringing a medical device for the spine to the market Abstract: 2.1 Introduction 2.2 Selection and sourcing of materials in medical device developments 2.3 Biocompatibility testing 2.4 Medical device regulation 2.5 Conclusions 2.6 Acknowledgement Chapter 3: Introduction to spinal pathologies and clinical problems of the spine Abstract: 3.1 Introduction 3.2 Degenerative spine disease 3.3 Spinal trauma 3.4 Spinal deformity 3.5 Malignancy 3.6 Infection 3.7 Conclusions Chapter 4: Forces on the spine Abstract: 4.1 Introduction 4.2 In vivo measured components of spinal loads 4.3 In vitro measured spinal load components 4.4 Analytical models for spinal load estimation 4.5 Recommendations for the simulations of loads for in vitro and numerical studies 4.6 Conclusions Chapter 5: Finite element modelling of the spine Abstract: 5.1 Introduction 5.2 Functional spine biomechanics and strength of numerical explorations 5.3 Geometrical approximations in spine finite element modelling 5.4 Numerical approximations: accuracy and computational cost 5.5 Constitutive models for the spine tissues 5.6 Simulating the mechanical loads on the spine 5.7 Model verifications and interpretations: the validation concept and quantitative validation 5.8 Future trends and conclusions: the virtual physiological spine Chapter 6: Osteobiologic agents in spine surgery Abstract: 6.1 Introduction 6.2 Bone formation and healing 6.3 Osteobiologics for spine fusion 6.4 Bone growth factors 6.5 Cellular biologics 6.6 Conclusions Part II: Spinal fusion and intervertebral discs Chapter 7: Spine fusion: cages, plates and bone substitutes Abstract: 7.1 Introduction 7.2 Spine fusion: historical concerns and surgical skills 7.3 Bone substitutes in spine fusion 7.4 Bone growth factors 7.5 Autologous bone marrow 7.6 Future trends Chapter 8: Artificial intervertebral discs Abstract: 8.1 Introduction 8.2 Structure and function of the intervertebral disc 8.3 The artificial intervertebral disc: design and materials 8.4 Fibre-reinforced composite m...

Sommario

Contributor contact details
Chapter 1: Introduction to biomaterials for spinal surgery
Abstract:
1.1 Introduction
1.2 Total disc replacement
1.3 Nucleus pulposus replacement
1.4 Materials for spinal applications
1.5 Conclusions
Part I: Fundamentals of biomaterials for spinal surgery
Chapter 2: An overview of the challenges of bringing a medical device for the spine to the market
Abstract:
2.1 Introduction
2.2 Selection and sourcing of materials in medical device developments
2.3 Biocompatibility testing
2.4 Medical device regulation
2.5 Conclusions
2.6 Acknowledgement
Chapter 3: Introduction to spinal pathologies and clinical problems of the spine
Abstract:
3.1 Introduction
3.2 Degenerative spine disease
3.3 Spinal trauma
3.4 Spinal deformity
3.5 Malignancy
3.6 Infection
3.7 Conclusions
Chapter 4: Forces on the spine
Abstract:
4.1 Introduction
4.2 In vivo measured components of spinal loads
4.3 In vitro measured spinal load components
4.4 Analytical models for spinal load estimation
4.5 Recommendations for the simulations of loads for in vitro and numerical studies
4.6 Conclusions
Chapter 5: Finite element modelling of the spine
Abstract:
5.1 Introduction
5.2 Functional spine biomechanics and strength of numerical explorations
5.3 Geometrical approximations in spine finite element modelling
5.4 Numerical approximations: accuracy and computational cost
5.5 Constitutive models for the spine tissues
5.6 Simulating the mechanical loads on the spine
5.7 Model verifications and interpretations: the validation concept and quantitative validation
5.8 Future trends and conclusions: the virtual physiological spine
Chapter 6: Osteobiologic agents in spine surgery
Abstract:
6.1 Introduction
6.2 Bone formation and healing
6.3 Osteobiologics for spine fusion
6.4 Bone growth factors
6.5 Cellular biologics
6.6 Conclusions
Part II: Spinal fusion and intervertebral discs
Chapter 7: Spine fusion: cages, plates and bone substitutes
Abstract:
7.1 Introduction
7.2 Spine fusion: historical concerns and surgical skills
7.3 Bone substitutes in spine fusion
7.4 Bone growth factors
7.5 Autologous bone marrow
7.6 Future trends
Chapter 8: Artificial intervertebral discs
Abstract:
8.1 Introduction
8.2 Structure and function of the intervertebral disc
8.3 The artificial intervertebral disc: design and materials
8.4 Fibre-reinforced composite materials: basic principles
8.5 Composite biomimetic artificial intervertebral discs
8.6 Future trends and conclusions
Chapter 9: Biological response to artificial discs
Abstract:
9.1 Introduction
9.2 The healing response to intervertebral disc implants
9.3 Infection as a cause of failure of implants
9.4 Loosening and the reaction to the products of wear and corrosion
9.5 Carcinogenicity and genotoxicity of metal implants
9.6 Conclusions
Part III: Vertebroplasty and scoliosis surgery
Chapter 10: The use of polymethyl methacrylate (PMMA) in neurosurgery
Abstract:
10.1 Introduction: a history of polymethyl methacrylate (PMMA)
10.2 Characteristics of polymethyl methacrylate (PMMA)
10.3 Preparation of polymethyl methacrylate (PMMA) for use in clinical practice
10.4 Clinical use of polymethyl methacrylate (PMMA) in neurosurgery
10.5 Developments in polymethyl methacrylate (PMMA)
10.6 Conclusions
Chapter 11: Optimising the properties of injectable materials for vertebroplasty and kyphoplasty
Abstract:
11.1 Introduction

Relazione

"This is a good reference on biomaterials. It will be of most interest to materials engineers, bioengineers and spine surgeons. It is well written and provides an extensive list of references." --Doody's Book Reviews

Dettagli sul prodotto

• Autori: L. Tanner Ambrosio
• Con la collaborazione di: L. Ambrosio (Editore), Luigi Ambrosio (Editore), Luigi (Director Ambrosio (Editore), Ambrosio Luigi (Editore), Elizabeth Tanner (Editore), Elizabeth (University of Glasgow Tanner (Editore), Tanner Elizabeth (Editore)
• Editore: Woodhead Publishing
• Lingue: Inglese
• Formato: Copertina rigida
• Pubblicazione: 12.03.2012
• EAN: 9781845699864
• ISBN: 978-1-84569-986-4
• Pagine: 652
• Serie: Woodhead Publishing Series in Biomaterials; Woodhead Publishing Series in; Woodhead Publishing Series in Biomaterials; Woodhead Publishing Biomateria
• Categorie: Scienze naturali, medicina, informatica, tecnica > Medicina > Tematiche generali; neurosurgery, MEDICAL / Surgery / Neurosurgery, TECHNOLOGY & ENGINEERING / Biomedical, Materials science, Biomedical engineering, TECHNOLOGY & ENGINEERING / Materials Science / General