5-HT4 Receptors in the Brain and Periphery

This book provides a comprehensive, up-to-date review of the distribution, pharmacology and physiology of central 5-hydroxytryptamine (5-HT)4 receptors. The 5-HT receptor subtypes exhibit a unique pharmacology, distribution and function, of which the 5-HT4 receptor has been one of the most intensively studied in recent years, both from a basic research standpoint and as a target for novel therapeutics.

Sommario

1. Medicinal Chemistry of 5-HT4 Receptor Ligands.- 2. Molecular Biology of 5-HT4 Receptors.- 3. Localization of 5-HT4 Receptors in Vertebrate Brain and Their Potential Behavioral Roles.- 4. Central 5-HT4 Receptors: Electrophysiology.- 5. Neurochemical Consequences Following Pharmacological Manipulation of Central 5-HT4 Receptors.- 6. 5-Hydroxytryptamine and Human Heart Function: The Role of 5-HT4 Receptors.- 7. 5-HT4 Receptors in Gastrointestinal Tract.- 8. 5-HT4 Receptors in Lower Urinary Tract Tissues.- 9. The 5-HT4 Receptor in the Adrenal Gland.- 10. Therapeutic Applications of 5-HT4 Receptor Agonists and Antagonists.

Dettagli sul prodotto

• Con la collaborazione di: Richard M. Eglen (Editore)
• Editore: Springer, Berlin
• Lingue: Inglese
• Formato: Copertina rigida
• Pubblicazione: 30.11.2011
• EAN: 9783540641643
• ISBN: 978-3-540-64164-3
• Pagine: 229
• Peso: 530 g
• Illustrazioni: XIII, 229 p. 19 illus.
• Serie: Biotechnology Intelligence Unit; Biotechnology Intelligence Unit
• Categoria: Scienze naturali, medicina, informatica, tecnica > Biologia > Biochimica, biofisica