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This book on the molecular gearings of fission yeast is cordially dedicated to Carsten Bresch, Michi Egel-Mitani, Herbert Gutz, Paul Nurse, Amar Klar, and Urs Leupold. With these candid personalities - all influential to the casting of my pro fessional and private career - I had the good fortune of sharing coauthorship at very significant steps towards developing a sensible touch for the subtle charm of this wonderful model organism (Bresch et al. 1968; Egel and Egel-Mitani 1974; Egel and Gutz 1981; Beach et al. 1982; Egel et al. 1984; Leupold et al. 1989). As to the timing of the book, repeated queries from participants at our Copenha gen EMBO courses on Molecular Genetics with the Fission Yeast Schizosaccharo myces pombe have indicated that a collective treatise on this subject would be highly welcome. This initial impression was overwhelmingly confirmed by the en thusiastic consent I met among the prospective authors when I first approached them on specific contributions to present their field of expertise - as well as by the encouraging support expressed by the Springer-Verlag crew. A notable prede cessor of this treatise, "The first attempt to assemble the lore of fission yeast" (Nasim et al. 1989), roughly coincided with the pioneering breakthrough of link ing the major cyclin-dependent kinase of fission yeast to cell cycle timing in gen eral - later awarded by the Nobel Prize to Paul Nurse.
Sommario
1 Fission Yeast in General Genetics.- 2 The Genome and Beyond.- 3 Protein Kinases Driving the Cell Cycle.- 4 Checkpoint Controls Halting the Cell Cycle.- 5 Stress Responses in S. pombe.- 6 DNA Replication in S. pombe.- 7 DNA Repair Pathways.- 8 The Retrotransposons of S. pombe.- 9 Mating-Type Cassettes: Structure, Switching and Silencing.- 10 Centromere and Kinetochore Structure and Function.- 11 Chromosome Cohesion and Segregation.- 12 Telomere Organization and Nuclear Movements.- 13 The Mitotic Spindle and Genome Segregation.- 14 The Fission Yeast Actomyosin Cytoskeleton.- 15 Regulation of Cytokinesis.- 16 Control of Cell Polarity and Morphogenesis in Fission Yeast.- 17 Cell Wall Synthesis.- 18 Mating-Type Control and Differentiation.- 19 Initiation of Meiosis.- 20 Control of Late Meiosis and Ascospore Formation.- 21 RNA Polymerases and Accessory Factors.- 22 Core Promoters in S. pombe: TATA and HomolD Boxes.- 23 Mechanism and Control of Pre-mRNA Splicing.- 24 Transcription Termination.- 25 Ubiquitin-Dependent Proteolysis by the Proteasome.- 26 Processing Proteases in S. pombe.- 27 Protein Glycosylation.- 28 Mitochondrial Genetics in a Petite-Negative Yeast.- 29 Fission Yeast Phylogenesis and Evolution.
Riassunto
The fission yeast Schizosaccharomyces pombe is the favoured tool of many productive research groups throughout the world, serving as a useful model for fundamental principles and mechanisms, such as genome organization, differential gene regulation, cell-cycle control, signal transduction, or cellular morphogenesis. This book collates the current state of knowledge derived from molecular studies in this simple eukaryotic microorganism. The entire sequence of its genome has been completed, emphasizing the comparative value and model status of this yeast. The individual chapters, highlighting up-to-date views on prominent aspects of molecular organization, were written by active research scientists, presenting the results of their investigations to other workers in neighbouring fields. This book intends to serve the fission yeast community as a handy source of reference for years to come. It will also be of particular value to the ever-increasing number of researchers starting to look into fission yeast affairs for comparative reasons from other platforms of molecular genetics and cell biology.
