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Informationen zum Autor Chris Peers and Gabriel G. Haddad are the authors of Hypoxia and Consequences, Volume 1177, published by Wiley. Klappentext International experts from academia, industry and government discuss the cellular mechanisms that underlie rapid and delayed responses to oxygen deprivation, known as hypoxia. This volume brings together researchers and clinicians from developmental and cellular biology, drug development, oncology, neurobiology and medicine to discuss 1) How hypoxia-inducible factors regulate development and physiology, 2) How cells sense changes in oxygen availability, and 3) How oxygen availability affects several pathologies like pulmonary hypertension, sleep apnea, cancer and neurodegeneration.NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas.ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member. Zusammenfassung International experts from academia, industry and government discuss the cellular mechanisms that underlie rapid and delayed responses to oxygen deprivation, known as hypoxia. Inhaltsverzeichnis Introduction to Hypoxia and Consequences: From Molecule to Malady ( Chris Peers, Navdeep S. Chandel, Gabriel G. Haddad ). Part I. Transcriptional Responses to Hypoxia. 1. Regulation of Vascularization by Hypoxia-Inducible Factor 1 ( Gregg L. Semenza ). 2. FIH-Dependent Asparaginyl Hydroxylation of Ankyrin Repeat Domain-Containing Proteins ( Matthew E. Cockman, James D. Webb, Peter J. Ratcliffe ). 3. From Polyps to People: A HIghly Familiar Response to Hypoxia ( R.J. Hampton-Smith, D.J. Peet ). 4. Maintaining Mammalian Iron and Oxygen Homeostasis: Sensors, Regulation, and Cross-Talk ( Ameen A. Salahudeen, Richard K. Bruick ). 5. Survival in Acute and Severe Low O2 Environment: Use of a Genetic Model System ( Priti Azad, Gabriel G. Haddad ). 6. Mitochondria and Hypoxic Signaling: A New View ( Robert O. Poyton, Pablo R. Castello, Kerri A. Ball, Dong Kyun Woo, Ning Pan ). 7. Pathophysiological Consequences of HIF Activation: HIF as a Modulator of Fibrosis ( Volker H. Haase ). 8. Mitochondrial Metabolism and Cancer ( Frank Weinberg, Navdeep S. Chandel ). Part II. Oxygen Sensing. 9. Molecular Imaging: Into In Vivo Interaction of HIF-1 and HIF-2 with ARNT ( Rebecca Konietzny, Anna König, Christoph Wotzlaw, André Bernadini, Utta Berchner-Pfannschmidt, Joachim Fandrey ). 10. Oxygen-Sensitive Potassium Channels in Chemoreceptor Cell Physiology: Making a Virtue of Necessity ( Constancio Gonzalez, Luis M. Vaquero, José Ramón López-López, M. Teresa Pérez-García ). 11. Ion Channel Regulation by AMPK: The Route of Hypoxia-Response Coupling in the Carotid Body and Pulmonary Artery ( A. Mark Evans, D. Grahame Hardie, Chris Peers, Christopher N. Wyatt, Benoit Viollet, Prem Kumar, Mark L. Dallas, Fiona Ross, Naoko Ikematsu, Heidi L. Jordan, Barbara L. Barr, J. Nicole Rafferty, Oluseye Ogunbayo ). 12. Hypoxia Selectively Inhibits KCNA5 Channels in Pulmonary Artery Smooth Muscle Cells ( Amy L. Firth, Oleksandr Platoshyn, Elena E. Brevnova, Elyssa D. Burg, Frank Powell, Gabriel H. Haddad, Jason X.-J. Yuan ). 13. Enzyme-Linked Oxygen Sensing by Potassium Channels ( Paul J. Kemp, Vsevolod Telezhkin, William J. Wilkinson, Ruth Mears, Stuart B. Hanmer, Hanne C. Gadeberg, Carsten T. Müller, Daniela Riccardi, Stephen P. Brazier ). 14. Oxygen Sensing in the Carotid Body ( José López-B...
