GLUTATHIONE AND SULFUR AMINO ACIDS

Informationen zum Autor Roberta Masella works as Head of the Human Nutrition Unit, Department of Veterinary Public Health and Food Safety, at Istituto Superiore di Sanità (ISS). She was previously head of the Gastroenterology Unit in the Laboratory of Metabolism and Pathological Biochemistry at ISS. She is the author of nearly 100 peer-reviewed publications, as well as seventy presentations at international congresses. Giuseppe (Joe) Mazza is the Principal Food and Bioscience Research Scientist at Agriculture and Agri-Food Canada, Summerland, British Columbia, and an adjunct professor in food science and nutrition at the Universities of Manitoba and British Columbia. A prolific author and editor of over 200 journal articles and twelve books, he is on the editorial boards of World of Food Science, Plant Foods for Human Nutrition, Italian Journal of Food Science, and Journal of Functional Foods. Klappentext The complex roles of glutathione and sulfur amino acids in human healthGlutathione (³-L-glutamyl-L-cysteinylglycine, GSH) is a major antioxidant acting as a free radical scavenger that protects the cell from reactive oxygen species (ROS). Sulfur amino acids (SAAs), such as methionine and cysteine, play a critical role in the maintenance of health. GSH depletion as well as alterations of SAA metabolism are linked to a host of disease states including liver cirrhosis, various pulmonary diseases, myocardial ischemia and reperfusion injury, aging, Parkinson's disease, Alzheimer's disease, sepsis, and others. This book provides researchers with a comprehensive review of the biochemistry, absorption, metabolism, biological activities, disease prevention, and health promotion of glutathione and sulfur amino acids.The twenty-two chapters explore such topics as:* Chemistry, absorption, transport, and metabolism of GSH and sulfur amino acids* Antioxidant and detoxification properties of GSH and sulfur amino acids, highlighting the enzymatic systems involved in antioxidant defenses* Biological activities of GSH and sulfur amino acids and their role in modulating cell processes* Role of GSH and sulfur amino acid deficiency and alteration in the onset of diseases and in aging* Protective effects exerted by GSH and sulfur amino acids when used as drugs, functional foods, and nutraceuticals in humans and animalsSpecial attention is paid to the molecular mechanisms for the modulation of transcription factors and enzyme activities, as well as the nutritional and therapeutic significance of dietary sulfur amino acids as shown in human and animal models.With more than 2,000 scientific references, this book provides food scientists, nutritionists, biochemists, food technologists, chemists, molecular biologists, and public health professionals with a comprehensive and up-to-date examination of glutathione and sulfur amino acids in human health and disease. Zusammenfassung Reviews the biochemistry, absorption, metabolism, biological activities, disease prevention, and health promotion of glutathione and sulfur amino acids Covers the nutritional and therapeutic significance of dietary sulfur amino acids, taking in account studies in humans and animal models. Inhaltsverzeichnis PREFACE. CONTRIBUTORS. I INTRODUCTION. 1 GLUTATHIONE AND THE SULFUR-CONTAINING AMINO ACIDS: AN OVERVIEW ( John T. Brosnan and Margaret E. Brosnan). 1.1 Introduction. 1.2 Why Sulfur-Containing Amino Acids? 1.3 S-Adenosylmethionine, Nature's Wonder Cofactor. 1.4 Glutathione. 1.5 Taurine-the Second Essential Sulfur-Containing Amino Acid? 1.6 Conclusions. Acknowledgments. References. II CHEMISTRY AND METABOLISM OF GSH AND SULFUR AMINO ACIDS. 2 SULFUR AMINO ACIDS CONTENTS OF DIETARY PROTEINS: DAILY INTAKE AND REQUIREMENTS ( Cécile Bos, Jean-François Huneau, and Claire Gaudichon). ...

List of contents

PREFACE.
 
CONTRIBUTORS.
 
I INTRODUCTION.
 
1 GLUTATHIONE AND THE SULFUR-CONTAINING AMINO ACIDS: AN OVERVIEW (John T. Brosnan and Margaret E. Brosnan).
 
Acknowledgments.
 
References.
 
II CHEMISTRY AND METABOLISM OF GSH AND SULFUR AMINO ACIDS.
 
2 SULFUR AMINO ACIDS CONTENTS OF DIETARY PROTEINS: DAILY INTAKE AND REQUIREMENTS (Cécile Bos, Jean-François Huneau, and Claire Gaudichon).
 
References.
 
3 CELLULAR COMPARTMENTALIZATION OF GLUTATHIONE (Federico V. Pallardó, Jelena Markovic, and José Vinã).
 
References.
 
4 INTESTINAL METABOLISM OF SULFUR AMINO ACIDS (Nancy Benight, Douglas G. Burrin, and Barbara Stoll).
 
References.
 
5 HEPATIC SULFUR AMINO ACID METABOLISM (Kevin L. Schalinske).
 
References.
 
III ANTIOXIDANT AND DETOXIFICATION ACTIVITIES.
 
6 GLUTATHIONE AND SULFUR CONTAINING AMINO ACIDS: ANTIOXIDANTAND CONJUGATION ACTIVITIES (Nils-Erik Huseby, Elisabeth Sundkvist, and Gunbjørg Svineng).
 
References.
 
7 GLUTAREDOXIN AND THIOREDOXIN ENZYME SYSTEMS: CATALYTIC MECHANISMS AND PHYSIOLOGICAL FUNCTIONS (Elizabeth A. Sabens and John J. Mieyal).
 
References.
 
8 METHIONINE SULFOXIDE REDUCTASES: A PROTECTIVE SYSTEM AGAINST OXIDATIVE DAMAGE (Herbert Weissbach and Nathan Brot).
 
Acknowledgment.
 
References.
 
IV BIOACTIVITY OF GSH AND SULFUR AMINO ACIDS AS REGULATORS OF CELLULAR PROCESSES.
 
9 REGULATION OF PROTEIN FUNCTION BY GLUTATHIONYLATION (Pietro Ghezzi and Paolo Di Simplicio).
 
References.
 
10 GSH, SULFUR AMINO ACIDS, AND APOPTOSIS (Giuseppe Filomeni, Katia Aquilano, and Maria Rosa Ciriolo).
 
Acknowledgments.
 
References.
 
11 METHIONINE OXIDATION: IMPLICATION IN PROTEIN REGULATION, AGING, AND AGING-ASSOCIATED DISEASES (Jackob Moskovitz and Derek B. Oien).
 
References.
 
12 SULFUR AMINO ACIDS, GLUTATHIONE, AND IMMUNE FUNCTION (Robert Grimble).
 
References.
 
V GSH AND SULFUR AMINO ACIDS IN PATHOLOGICAL PROCESSES.
 
13 SULFUR AMINO ACID DEFICIENCY AND TOXICITY: RESEARCH WITH ANIMAL MODELS (David H. Baker and Ryan N. Dilger).
 
References.
 
14 HUMAN PATHOLOGIES AND ABERRANT SULFUR METABOLISM (Danyelle M. Townsend, Haim Tapiero, and Kenneth D. Tew).
 
References.
 
15 INBORN ERRORS OF GSH METABOLISM (llinor Ristoff).
 
Acknowledgments.
 
References.
 
16 HOMOCYSTEINE METABOLISM AND PATHOLOGICAL IMPLICATIONS: THE HOMOCYSTEINE THIOLACTONE HYPOTHESIS OF VASCULAR DISEASE (Hieronim Jakubowski).
 
References.
 
17 HOMOCYSTEINE AND CARDIOVASCULAR DISEASE (Jayanta R. Das and Sanjay Kaul).
 
References.
 
18 HOMOCYSTEINE AND NEUROLOGICAL DISORDERS (Rodica E. Petrea and Sudha Seshadri).
 
References.
 
19 GLUTATHIONE, SULFUR AMINO ACIDS, AND CANCER (José M. Estrela, Julian Carretero, and Angel Ortega).
 
References.
 
VI GSH AND SULFUR AMINO ACIDS AS DRUGS AND NUTRACEUTICALS.
 
20 GSH, GSH DERIVATIVES, AND ANTIVIRAL ACTIVITY (Anna Teresa Palamara, Lucia Nencioni, Rossella Sgarbanti, and Enrico Garaci).
 
References.
 
21 N-ACETYL CYSTEINE AND CYTOPROTECTIVE EFFECTS AGAINST BRONCHOPULMONARY DAMAGE: FROM IN VITRO STUDIES TO CLINICAL APPLICATION (Richard Dekhuijzen).
 
References.
 
22 TAURINE AS DRUG AND FUNCTIONAL FOOD COMPONENT (Ramesh C. Gupta, Massimo D'Archivio, and Roberta Masella).
 
References.
 
SUBJECT INDEX.

Product details

• Authors: R Masella, Robert Masella, Roberta Masella, Roberta Mazza Masella, Masella Roberta, MASELLA ROBERTA MAZZA GIUSEPPE, Giuseppe Mazza, Mazza Giuseppe
• Assisted by: Roberta Masella (Editor), Giuseppe Mazza (Editor)
• Publisher: Wiley, John and Sons Ltd
• Languages: English
• Product format: Hardback
• Released: 17.07.2009
• EAN: 9780470170854
• ISBN: 978-0-470-17085-4
• No. of pages: 598
• Subjects: Natural sciences, medicine, IT, technology > Chemistry; Chemie, Biochemie, aminosäuren, Life Sciences, Biowissenschaften, chemistry, Zell- u. Molekularbiologie, Cell & Molecular Biology, Food Science & Technology, Lebensmittelforschung u. -technologie, Biochemie u. Chemische Biologie, Biochemistry (Chemical Biology), Allg. Lebensmittelforschung u. -technologie