Nutraceuticals and Natural Product Derivatives - Disease Prevention & Drug Discovery

Introduces readers to the growing applications of nutraceuticals and other natural product derivatives
 
This comprehensive book presents a prophylactic and therapeutic approach to chronic disease prevention strategy by highlighting the translational potential of plant-derived dietary and non-dietary factors from epidemiological, laboratory, and clinical studies. It also shares the experiences of highly reputed experts working in the area of phytomedicine and nutraceutical agents in chemoprevention, to promote the significance of natural products and dietary factors as an elite priority for containing chronic diseases in the human population.
 
Nutraceuticals and Natural Product Derivatives: Disease Prevention & Drug Discovery starts by examining natural food sources for the control of glycemia and the prevention of diabetic complications. It then looks at the anti-aging effects of sulfur-containing amino acids and nutraceuticals, and the potential of garcinia fruits to combat metabolic syndrome. Other topics covered include honey- and propolis-mediated regulation of protein networks in cancer cells; recent trends in drug discovery against Alzheimer's disease; the therapeutic potential of metalloherbal nanoceuticals; and much more.
* Offers an alternative, natural approach to the prevention of chronic diseases
* Emphasizes the potential of plant-derived dietary and non-dietary factors from epidemiological, laboratory, and clinical studies
* Features contributions from world-renowned experts in the field of phytomedicine and nutraceutical agents in chemoprevention
* Includes prevention strategies in normal/risk populations through routine inclusion of specific dietary regimens and as therapeutic strategy for better management through adjuvant interventions with conventional treatment protocols
 
Nutraceuticals and Natural Product Derivatives: Disease Prevention & Drug Discovery will appeal to graduate students and professionals in cell and molecular biology, translational research, pharmacology/drug discovery, medicinal chemistry, and clinical nutrition.

List of contents

List of Contributors xvii
 
Foreword xxi
 
Preface xxv
 
Books Description xxix
 
Expert Commentary xxxi
 
1 Natural Food Sources for the Control of Glycemia and the Prevention of Diabetic Complications 1
Carlo Pesce, Carla Iacobini, and Stefano Menini
 
1.1 Introduction: Obesity, Metabolic Syndrome, and Type 2 Diabetes Epidemics: The Role of Nutrition 1
 
1.2 Phytochemicals of Nutraceutical Importance and Functional Foods of Plant Origin 3
 
1.2.1 Dietary Oils 3
 
1.2.2 Vegetables and Fruits 4
 
1.3 Nutraceuticals and Functional Foods of Animal Origin 8
 
1.3.1 The Case of Carnosine 8
 
1.4 Nutraceuticals of Both Plant and Animal Origin 9
 
1.5 Probiotics, Prebiotics, and Symbiotics 12
 
1.6 Conclusion 15
 
References 17
 
2 Anti-Aging Effects of Sulfur-Containing Amino Acids and Nutraceuticals 25
Geetika Garg, Abhishek Kumar Singh, Sandeep Singh, and Syed Ibrahim Rizvi
 
2.1 Aging and Nutrition 25
 
2.2 Natural Antioxidants 26
 
2.2.1 Sulfur-Containing Amino Acids and Their Role as Antioxidants 26
 
2.2.2 Anti-Aging Effects of L-Cysteine 27
 
2.3 N-Acetyl-L-Cysteine 28
 
2.3.1 Neuroprotective Effects of N-Acetyl-L-Cysteine 29
 
2.3.2 N-Acetyl-L-Cysteine in Combination with Other Antioxidants 29
 
2.4 Methionine 30
 
2.4.1 Methionine Restriction 30
 
2.5 Sulfur-Containing Nutraceuticals and Foods Rich in Sulfur-Containing Amino Acids 31
 
2.5.1 Whey Protein 32
 
2.5.2 Anti-Aging Effects of Whey Protein 32
 
2.6 Conclusion 33
 
Acknowledgments 33
 
Conflict of Interest 33
 
References 33
 
3 Garcinia Fruits: Their Potential to Combat Metabolic Syndrome 39
Oliver John, Lindsay Brown, and Sunil K. Panchal
 
3.1 Introduction 39
 
3.2 Overview of Compounds in Garcinia Species 40
 
3.2.1 Garcinia mangostana 44
 
3.2.1.1 Chemical Properties 51
 
3.2.1.2 Biological Activities of G. mangostana 51
 
3.2.1.3 Toxicity 55
 
3.2.2 Garcinia cambogia 56
 
3.2.2.1 Chemical Properties 56
 
3.2.2.2 Biological Activities 57
 
3.2.2.3 Toxicity 59
 
3.2.2.4 Future Research 59
 
3.2.3 Garcinia humilis 59
 
3.2.3.1 Chemical Properties 59
 
3.2.3.2 Biological Activities 60
 
3.2.4 Garcinia dulcis 61
 
3.2.4.1 Chemical Properties 61
 
3.2.4.2 Biological Properties 61
 
3.2.4.3 Potential Research 62
 
3.3 Limitations 62
 
3.4 Conclusion 64
 
References 64
 
4 Pro-Angiogenic and Anti-Angiogenic Effects of Small Molecules from Natural Products 81
Jingyi Ma and Xuelin Zhou
 
4.1 Biological mechanisms of Angiogenesis 81
 
4.2 Pharmacological Models for Angiogenesis Study 82
 
4.3 Pro-Angiogenic Effects of Small Molecules from Natural Products 83
 
4.3.1 Natural Products as Sources for Screening Pro-Angiogenic Stimulators 83
 
4.3.2 Flavonoids 84
 
4.3.3 Saponins 84
 
4.3.4 Salvianolic Acids 85
 
4.3.5 Other Small Molecules 85
 
4.3.5.1 Ferulic Acid 85
 
4.3.5.2 Aloe vera-Derived Compounds 85
 
4.3.6 Summary 86
 
4.4 Anti-Angiogenic Effects of Small Molecules from Natural Products 86
 
4.4.1 Natural Products as Sources for Screening Angiogenic Inhibitors 87
 
4.4.2 Flavonoids 87
 
4.4.3 Diterpenoids 89
 
4.4.4 Polyphenol 90
 
4.4.5 Saponins 92
 
4.4.6 Alkaloids 93
 
4.4.7 Chalcone 93
 
4.4.8 Anthraquinone 93
 
4.4.9 Carotenoi

About the author

About the Editors Mohammad Fahad Ullah, is an Assistant Professor of Biochemistry in the Department of Medical Laboratory Technology (FAMS) and a Research Scientist at Prince Fahd Research Chair, University of Tabuk, Saudi Arabia. Aamir Ahmad, is an Assistant Professor of Oncologic Sciences at University of South Alabama's Mitchell Cancer Institute, Mobile, AL, USA.

Summary

Introduces readers to the growing applications of nutraceuticals and other natural product derivatives

This comprehensive book presents a prophylactic and therapeutic approach to chronic disease prevention strategy by highlighting the translational potential of plant-derived dietary and non-dietary factors from epidemiological, laboratory, and clinical studies. It also shares the experiences of highly reputed experts working in the area of phytomedicine and nutraceutical agents in chemoprevention, to promote the significance of natural products and dietary factors as an elite priority for containing chronic diseases in the human population.

Nutraceuticals and Natural Product Derivatives: Disease Prevention & Drug Discovery starts by examining natural food sources for the control of glycemia and the prevention of diabetic complications. It then looks at the anti-aging effects of sulfur-containing amino acids and nutraceuticals, and the potential of garcinia fruits to combat metabolic syndrome. Other topics covered include honey- and propolis-mediated regulation of protein networks in cancer cells; recent trends in drug discovery against Alzheimer's disease; the therapeutic potential of metalloherbal nanoceuticals; and much more.
* Offers an alternative, natural approach to the prevention of chronic diseases
* Emphasizes the potential of plant-derived dietary and non-dietary factors from epidemiological, laboratory, and clinical studies
* Features contributions from world-renowned experts in the field of phytomedicine and nutraceutical agents in chemoprevention
* Includes prevention strategies in normal/risk populations through routine inclusion of specific dietary regimens and as therapeutic strategy for better management through adjuvant interventions with conventional treatment protocols

Nutraceuticals and Natural Product Derivatives: Disease Prevention & Drug Discovery will appeal to graduate students and professionals in cell and molecular biology, translational research, pharmacology/drug discovery, medicinal chemistry, and clinical nutrition.

Product details

• Authors: Aamir Ahmad, M Ullah, Mohammad Ullah, Mohammad Ahmad Ullah, Mohammad Fahad Ullah, Mohammad Fahad Ahmad Ullah
• Assisted by: Ahmad (Editor), Ahmad (Editor), Aamir Ahmad (Editor), Ahmad Aamir (Editor), Mohamma Fahad Ullah (Editor), Mohammad Fahad Ullah (Editor), Mohammad Ullah (Editor), Mohammad Fahad Ullah (Editor), Ullah Mohammad Fahad (Editor)
• Publisher: Wiley, John and Sons Ltd
• Languages: English
• Product format: Hardback
• Released: 31.01.2019
• EAN: 9781119436676
• ISBN: 978-1-119-43667-6
• No. of pages: 456
• Subjects: Natural sciences, medicine, IT, technology > Biology > Agriculture, horticulture; forestry, fishing, food; Medizin, Stoffwechsel, Stoffwechselkrankheiten, Functional Food, Health & Social Care, Gesundheits- u. Sozialwesen, Medical Science, Food Science & Technology, Lebensmittelforschung u. -technologie, Functional Food, Nutraceuticals, Functional Foods & Nutraceuticals, Stoffwechsel u. Biochemie der Ernährung, Metabolism & Biochemistry of Nutrition, metabolic disease