Read more
Thoroughly revised, with either entirely new or completely updated contents, this is a practical manual for the small and large-scale preparation of enantiomerically pure products. The result is a vital resource for meeting the highest purity standards in the manufacture of chiral pharmaceuticals, food additives and related compounds. All the approaches covered here are highly relevant to modern manufacturing and quality control schemes in the pharmaceutical and biotech industries, addressing the increasingly important issue of drug safety in view of tougher regulatory standards worldwide.
List of contents
1 Enantiomeric separations using macrocyclic glycopeptide stationary phases2 The Role of Polysaccharides in Chiral Separations by Liquid Chromatography and Capillary Electrophoresis3 Analytical and preparative potential of immobilized polysaccharide-derived chiral stationary phases4 Chiral separations using supercritical fluid chromatography5 Chiral ligand exchange in HPLC and CE6 Advances in Simulated Moving Bed Chromatographic separations7 Less common applications of enantioselective HPLC using the SMB technology in the pharmaceutical industry8 Enatiomer Separation by Chiral Crown Ether Stationary phases9 Chiral Separation of amino acids and hydroxy acids in HPLC with copper(II) complexes added to the eluent10 Chiral Capillary Electrophoresis11 Techniques in preparative chiral separations12 Separation of enantiomers using molecularly imprinted polymers13 Enantioselective Biosensors14 Chiral analysis using CEC-UV and CEC-MS15 Chiral analysis using MEKC-UV and MEKC-MS16 Polarimeter Chiral Detectors in Enantioseparations17 Preparative Chiral Chromatography - a powerful and efficient tool in drug discovery
About the author
Dr. Ganapathy Subramanian is a biotechnology consultant with over 30 years experience in both industry and academia, in the application and development of processing, purification methodologies and chromatographic systems for large-scale use in environmental science, food science, perfumery cosmetics and pharmaceuticals. He has also taught extensively in the area of food and medical technology.A chemistry graduate from Madras, India, Dr Subramanian was awarded his Doctorate from the University of Glasgow, for work on natural products, and his main research interests lie in the utilisation of natural material separation processes and bio-conversions.Dr. Subramanian has written and edited a number of books and articles in the field of biotechnology. For the last 10 years, he has been organizing conferences promoting the integration and sharing of knowledge between academia and industry.
Summary
Thoroughly revised, with either entirely new or completely updated contents, this is a practical manual for the small and large-scale preparation of enantiomerically pure products. The result is a vital resource for meeting the highest purity standards in the manufacture of chiral pharmaceuticals, food additives and related compounds. All the approaches covered here are highly relevant to modern manufacturing and quality control schemes in the pharmaceutical and biotech industries, addressing the increasingly important issue of drug safety in view of tougher regulatory standards worldwide.
Additional text
From reviews of the first edition:
'Publication of this book is timely, and of immense value to the growth of this field'
Journal of Food Science
'A team of experts from academic and industrial laboratories throughout the world have compiled their findings and experience to make this book an exceptionally timely and unique contribution to the field'
European Journal of Drug Metabolism
'The dense mass of information contained in this book will make it a valuable resource ...'
Chemical Engineering Research
'... this is a worthwhile addition to the expanding chiral literature and the book should be of value to those working in this field'
The Analyst
'This book is a valuable reference and should find a readership among scientists in the field of pharmaceutical sciences.'
Chirality
'...this book can be recommended to analysts confronted with chiral separations.'
Journal of Chromatography A
'In conclusion this is a useful volume written on the whole by workers in the field and deserving a place in the bench of doing chiral separations.'
Human and Experimental Technology
Report
"...Die reviewartig gegliederten Beiträge ermöglichen dem Leser ein umfassendes, detailiertes Bild - allein die Informationsdichte empfiehlt es als Nachschlagewerk."Chemie Report, 10/2007
