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Informationen zum Autor Adrian C. Michael, Laura Borland Klappentext Electrochemical Methods for Neuroscience provides an updated summary of the current! albeit evolving! state of the art and lays the scientific foundation for incorporating electrochemical techniques into emerging research. With contributions from pioneers in the field! the text outlines the applications and benefits of a wide range of electrochemical techniques. It explores the methodology and protocols behind the acquisition of neurochemical and neurobiological data through continuous amperometry! fast scan cyclic voltammetry! high-speed chronoamperometry! ion-selective microelectrodes! enzyme based microelectrodes! and in vivo voltammetry with telemetry. The text also introduces emerging concepts in the field such as the correlation of electrochemical recordings with information obtained from patch clamp! electrophysiological! and behavioral techniques. Zusammenfassung Since the first implant of a carbon microelectrode in a rat 35 years ago, there have been substantial advances in the sensitivity, selectivity and temporal resolution of electrochemical techniques. This book lays the scientific foundation for incorporating electrochemical techniques into the research programs in the neuroscience disciplines. Inhaltsverzeichnis Introduction to Electrochemical Methods in Neuroscience, Rapid Dopamine Release in Freely Moving Rats, Presynaptic Regulation of Extracellular Dopamine as Studied by Continuous Amperometry in Anesthetized Animals, Fast Scan Cyclic Voltammetry of Dopamine and Serotonin in Mouse Brain Slices, High-Speed Chronoamperometry to Study Kinetics and Mechanisms for Serotonin Clearance in vivo, Using High-Speed Chronoamperometry Coupled with Local Dopamine Application to Assess Dopamine Transporter Function, Determining Serotonin and Dopamine Uptake Rates in Synaptosomes Using High-Speed Chronoamperometry, Using Fast-Scan Cyclic Voltammetry to Investigate Somatodendritic Dopamine Release, From Interferant Anion to Neuromodulator: Ascorbate Oxidizes Its Way to Respectability, Biophysical Properties of Brain Extracellular Space Explored with Ion-Selective Microelectrodes, Integrative Optical Imaging and Related Techniques, Hydrogen Peroxide as a Diffusible Messenger: Evidence from Voltammetric Studies of Dopamine Release in Brain Slices, In Vivo Voltammetry with Telemetry, Oxidative Stress at the Single Cell Level, Electrochemistry at the Cell Membrane/Solution Interface, The Patch Amperometry Technique: Design of a Method to Study Exocytosis of Single Vesicles, Amperometric Detection of Dopamine Exocytosis from Synaptic Terminals, Scanning Electrochemical Microscopy as a Tool in Neuroscience, Principles, Development and Applications of Self-Referencing Electrochemical Microelectrodes to the Determination of Fluxes at Cell Membranes, Second-by-Second Measures of L-Glutamate and Other Neurotransmitters Using Enzyme-Based Microelectrode Arrays, Telemetry for Biosensor Systems, The Principles, Development and Application of Microelectrodes for the in vivo Determination of Nitric Oxide, In vivo Fast-scan Cyclic Voltammetry of Dopamine near Microdialysis Probes...
