Recent Advances in Parkinsons Disease - Part Ii: Translational and Clinical Research

An overview of topics and approaches to PD research, from molecules, to brain circuits, to clinical and therapeutic applications. It provides views and perspectives for future research. It includes chapters with comprehensive background information.

List of contents

Section I: Animal models of PD

1. What have we learned from Drosophila Models of Parkinson's Disease? - Ming Guo


2. Neurotoxic in vivo models of Parkinson's disease: recent advances - Timothy Greenamyre & Jason R. Cannon


3. Behavioural analysis of motor and non-motor symptoms in rodent models of Parkinson's disease - Stephen B. Dunnett & Mariah Lelos


4. Genetic mouse models of Parkinson's disease: the state of the art - Marie-Francoise Chesselet & Iddo Magen


5. Viral vector mediated overexpression of a-synuclein as a progressive model of Parkinson's disease - Anders Bjorklund, Ayse Ulusoy, Mickael Decressac, Deniz Kirik


6. Modelling inflammatory pathogenesis of Parkinson's Disease - Malu Tansey & Christopher J. Barnum


7. The MPTP-lesioned non-human primate models of Parkinson's disease. Past, present and future - Susan Fox & Jonathan Brotchie
Section II: Exploring PD with brain imaging


8. Abnormal Metabolic Brain Networks in Parkinson's Disease: From Blackboard to Bedside - David Eidelberg & Chris C. Tang


9. Imaging the Nigrostriatal System to Monitor Disease Progression and Treatment-Induced Complications - Jon Stoessl & Renju Kuriakose


10. Brain imaging after neural transplantation - Paola Piccini & Marios Politis


11. Imaging non-motor aspects of Parkinson's disease - David Brooks & Nicola Pavese
Section III: Frontiers in PD treatment


12. Gene therapy for dopamine replacement - Deniz Kirik & Tomas Björklund, Erik Ahlm Cederfjäll


13. Neurotrophic Factor Therapy for Parkinson's disease - Jeffrey Kordower, Rangasamy Suresh Babu, Katherine Soderstrom, Roy A.E. Bakay


14. Neural grafting in Parkinson's disease: Problems and possibilities - Patrik Brundin, Roger A Barker and Malin Parmar


15. Neural grafting in Parkinson´s disease: Unraveling the mechanisms underlying graft-induced dyskinesia - Emma L Lane, Anders Björklund, Stephen B Dunnett, Christian Winkler


16. Deep Brain Stimulation: State of the Art and Novel Stimulation Targets - Andres Lozano & Francisco A. Ponce


17. The challenge of Non-Motor Symptoms in Parkinson´s Disease - Ray Chaudhuri & Per Odin

Product details

• Authors: Anders Bjorklund, M. Angela Cenci
• Assisted by: Anders Bjorklund (Editor), M. Angela Cenci (Editor), Angela Cenci-Nilsson (Editor)
• Publisher: ELSEVIER SCIENCE BV
• Languages: English
• Product format: Hardback
• Released: 13.10.2010
• EAN: 9780444537508
• ISBN: 978-0-444-53750-8
• No. of pages: 368
• Series: Progress in Brain Research; Progress in Brain Research
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Non-clinical medicine; MEDICAL / Neurology, Neurology & clinical neurophysiology, Neurology and clinical neurophysiology