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This book effectively summarizes our knowledge of recent advances in prostate cancer. It focuses on our state-of-the-art understanding of risk factors, prevention, detection, prognosis and treatment of prostate cancer and identifies basic science findings that are being translated into clinical practice. In addition, the book singles out key areas of research that have potential for clinical translation. Both basic scientists and clinicians will be invited to provide up-to-date reviews in each area of prostate cancer. During the last decade the pace of clinical discovery and the scientific advances in prostate cancer have been very rapid. For instance, currently there are more than 100 drugs in the pharmaceutical pipeline that have the potential for clinical management of prostate cancer. Therefore, it has been very difficult for clinicians and basic scientists to keep pace with the field as a whole. Recently, some of these discoveries are already having an impact on clinical practice. For example, the discovery of the androgen receptor gene amplification in prostate cancer has led to the development of a "super-antiandrogen," which is being tested in clinical trials. Also, recent knowledge of androgen synthesis in prostate cancer cells has led to clinical trials with steroid-metabolism inhibitors. Finally, robotic surgery has also dramatically changed clinical practice. Thus, this important book serves to provide readers with a one-stop overview of the field of prostate cancer research and its translation into the clinical arena.
List of contents
Pathology of Prostate (L True); Genetic Basis for Prostate Cancer (S Loeb & W B Isaacs); Androgen Receptor Converts from a Growth Suppressor in the Normal Prostate to an Oncogene in Prostate Cancer (D J Vander Griend & J T Isaacs); Etiology: Role of ETS Factor Gene Fusions (J Wang & M Ittmann); Role of Inflammation in Prostate Cancer (W Nelson & S Kimmel); Tumor Biology (E Benedettini et al.); The Androgen Receptor (K Datta et al.); Intracrine Synthesis of Androgens by Prostate Cancer in Response to Androgen Deprivation Therapy (J L Mohler et al.); Genetically Engineered Mouse Models in Prostate Cancer Research (F Wang et al.); Detection of Prostate Cancer: PSA (H Lilja & F Schroeder); Imaging of Prostate Cancer (E Mena et al.); Treatment of Prostate Cancer with Radiation (A Diaz & A Pollack); Treatment of Prostate Cancer: Surgery (V P Laudone et al.); Treatment of Prostate Cancer - Hormonal Therapy (A Elfiky & P Kantoff); Chemotherapy for Castration-Resistant Prostate Cancer (G Iyer et al.); Novel Therapeutic Approaches to Advanced Prostate Cancer (M K Tollefson & E D Kwon); Prevention of Prostate Cancer (I Thompson).
