NF-kB in Health and Disease

Nearly 25 years of intensive research have uncovered many diverse functions for the dimeric transcription factor known as NF-kappaB (nuclear factor-kappaB). NF-kappaB affects most aspects of cellular physiology-from immunity and inflammation to apoptosis, cell survival, growth, and proliferation

List of contents

Preface.- Understanding the Logic of IkappaB:NF-kappaB Regulation in Structural Terms.- IKK regulation and human genetics.- Specialized chromatin patterns in the control of inflammatory gene expression.- Macrophages and NF-kappaB in Cancer.- NF- B/Rel proteins and the humoral immune responses of Drosophila melanogaster.- IKK and NF-kappaB mediated functions in carcinogenesis.- Control of NF-kappaB activity by proteolysis.- NF-kappaB as a target for oncogenic viruses.- NF-kappaB and Innate Immunity.- Inhibition of NF-kappaB signaling as a strategy in disease therapy.- NF- B and mucosal homeostasis.- NF-kappaB In liver cancer - the plot thickens.- Subject index.

Summary

Nearly 25 years of intensive research have uncovered many diverse functions for the dimeric transcription factor known as NF-kappaB (nuclear factor-kappaB). NF-kappaB affects most aspects of cellular physiology—from immunity and inflammation to apoptosis, cell survival, growth, and proliferation

Product details

• Assisted by: Michae Karin (Editor), Michael Karin (Editor)
• Publisher: Springer, Berlin
• Languages: English
• Product format: Hardback
• Released: 01.09.2010
• EAN: 9783642160165
• ISBN: 978-3-642-16016-5
• No. of pages: 268
• Weight: 582 g
• Illustrations: VIII, 268 p.
• Series: Current Topics in Microbiology and Immunology; Current Topics in Microbiology and Immunology
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Non-clinical medicine; C, Biomedical and Life Sciences, Cancer Research, Cancer Biology, oncogenic viruses, mucosal homeostasis, tumor-associated macrophages, regulation of NF-kB signalling