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The advent of non-invasive imaging technology, such as magnetic resonance imaging (MRI), has allowed biologists and clinicians to make great strides in unraveling the secrets of the brain. In Magnetic Resonance Neuroimaging: Methods and Protocols, expert researchers in the field provide a comprehensive collection of experimental MRI protocols that can be used to non-invasively interrogate the healthy and diseased brain. The chapters are divided into general techniques, such as the measurement of relaxivity, magnetic resonance spectroscopy, diffusion tensor imaging, and MR reporter genes, as well as specific applications in brain imaging, for example, phenotyping transgenic animals, detecting amyloid plaques, and fMRI in psychiatry. As a volume in the highly successful Methods in Molecular Biology(TM) series, this work contains the type of detailed description and implementation advice that is crucial for getting optimal results.Thorough and cutting-edge, Magnetic Resonance Neuroimaging: Methods and Protocols serves neuroscientists, clinical neurologists, psychiatrists, and radiologists with an excellent compendium of methods easily applied to both animal and human studies and certain to be an excellent resource for translational research.
List of contents
From Molecules to Man: The Dawn of a Vitreous Man.- Magnetic Resonance Safety.- Measuring the Absolute Water Content Of the Brain Using Quantitative MRI.- Magnetic Resonance Relaxation and Quantitative Measurement in the Brain.- Magnetic Resonance Brain Image Processing and Arithmetic with FSL.- Diffusion Tensor Imaging.- Manganese-Enhanced Magnetic Resonance Imaging (MEMRI).- Sodium MRI.- MR Spectroscopy and Spectroscopic Imaging of the Brain.- Amide Proton Transfer Imaging of the Human Brain.- High Field MRI of Brain Iron.- Magnetic Resonance Imaging-Based Mouse Brain Atlas and Its Applications.- CEST MRI Reporter Genes.- Longitudinal Functional Magnetic Resonance Imaging in Animal Models.- Combining EEG and fMRI.- MR Angiography and Arterial Spin Labeling.- MRI Phenotyping of Genetically Altered Mice.- Gene Targeting MRI: Nucleic Acid-Based Imaging and Applications.- Molecular MRI Approaches to the Detection of CNS Inflammation.- Brain Redox Imaging.- Systems Biology Approach to Imaging of Neural Stem Cells.- MRI of Transplanted Neural Stem Cells.- MRI of Experimental Gliomas.- MRI in Experimental Stroke.- Non-Invasive MR Imaging of Neurodegeneration in a Rodent Model of Parkinson's Disease.- Detecting Amyloid-beta Plaques in Alzheimer's Disease.- Assessing Subtle Structural Changes in Alzheimer's Disease Patients.- Pharmacological Application of fMRI.- MRI of Neuronal Plasticity in Rodent Models.- MR-Guided Focused Ultrasound for Brain Ablation and Blood-Brain Barrier Disruption.
Summary
The advent of non-invasive imaging technology, such as magnetic resonance imaging (MRI), has allowed biologists and clinicians to make great strides in unraveling the secrets of the brain. In Magnetic Resonance Neuroimaging: Methods and Protocols, expert researchers in the field provide a comprehensive collection of experimental MRI protocols that can be used to non-invasively interrogate the healthy and diseased brain. The chapters are divided into general techniques, such as the measurement of relaxivity, magnetic resonance spectroscopy, diffusion tensor imaging, and MR reporter genes, as well as specific applications in brain imaging, for example, phenotyping transgenic animals, detecting amyloid plaques, and fMRI in psychiatry. As a volume in the highly successful Methods in Molecular Biology™ series, this work contains the type of detailed description and implementation advice that is crucial for getting optimal results.
Thorough and cutting-edge, Magnetic Resonance Neuroimaging: Methods and Protocols serves neuroscientists, clinical neurologists, psychiatrists, and radiologists with an excellent compendium of methods easily applied to both animal and human studies and certain to be an excellent resource for translational research.
