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Informationen zum Autor MARIE-HÉLÈNE VERLHAC, CNRS/Université Pierre et Marie Curie, Paris, France. ANNE VILLENEUVE, School of Medicine, Stanford University, USA. Klappentext Oogenesis - the process by which female germ cells develop into mature eggs, or ova - is a complex process involving many important elements of developmental and cellular biology: from cell-cell interactions, complex signalling cascades, specialized cell cycles and cytoskeleton organization. Oocytes from various species (including clam, starfish, xenopus and mouse) are excellent model systems to study the biochemistry of cell division with important implications for basic and clinical research.This book describes the entire process of oogenesis in chronological order with contributions from leading international researchers and chapters covering medical and ethical considerations in oogenic biology. Topics include sex determination and gonadal development, control of meiotic chromosome pairing and homologous recombination, control of meiotic divisions and the remodelling of the oocyte into a totipotent zygote as well as medically-assisted reproduction.This volume is an essential resource for all students, researchers and clinicians in developmental and reproductive biology.Key features:* Reaches beyond the study of simply meiosis to cover all aspects of oogenesis* Synthesizes recent advances in the field, drawing on studies from different model species* Chapter sequence designed to follow the time line in vivo* Written by an international panel of expert researchers Zusammenfassung Oogenesis - the process by which female germ cells develop intomature eggs, or ova - is a complex process involving many importantelements of developmental and cellular biology: from cell-cellinteractions, complex signalling cascades, specialized cell cyclesand cytoskeleton organization. Inhaltsverzeichnis List of Contributors. Foreword. (Tim Hunt) Section I: Oocyte Determination. Chapter 1: The Sperm/Oocyte Decision, a C. elegans Perspective ( Ronald Ellis ). Chapter 2: Sex Determination and Gonadal Development ( Alexander Combes, Cassy Spiller and Peter Koopman ). Chapter 3 : Clytia hemisphaerica: A Cnidarian Model for Studying Oogenesis ( Aldine Amiel, Patrick Chang, Tsuyoshi Momose and Evelyn Houliston ). Section II: Oocyte Growth. Chapter 4: Soma-Germline Interactions in the Ovary: an Evolutionary Perspective ( David Albertini and John Bromfield ). Section III: Homologous Chromosome Pairing and Recombination. Chapter 5: Homologous Chromosome Pairing and Synapsis during Oogenesis ( Susanna Mlynarczyk-Evans and Anne Villeneuve ). Chapter 6: Meiotic Recombination in Mammals ( Sabine Santucci-Darmanin and Fre¿de¿ric Baudat ). Section IV: Meiosis Resumption. Chapter 7: Initiation of the Meiotic Prophase-to-Metaphase Transition in Mammalian Oocytes ( Laurinda A. Jaffe and Rachael P. Norris ). Chapter 8: Oocyte-Specific Translational Control Mechanisms ( Isabel Novoa, Carolina Eliscovich, Eula`lia Belloc and Raül Me¿ndez ). Chapter 9: MPF and the Control of Meiotic Divisions: Old Problems, New Concepts ( Catherine Jessus ). Section V: The Cytological Events of Meiotic Divisions. Chapter 10: Meiotic Spindle Assembly and Chromosome Segregation in Oocytes ( Julien Dumont and Ste¿phane Brunet ). Chapter 11: Mechanisms of Asymmetric Division in Metazoan Meiosis ( Marie-He¿le`ne Verlhac and Karen Wingman Lee ). Section VI: Biological Clocks Regulating Meiotic Divisions. Chapter 12: The Control of the Metaphase-to-Anaphase Transition in Meiosis ( M. Emilie Terret ). Chapter 13: Mechanisms Controlling Maintenance and Exit of the CSF Arrest ( Thierry Lorca and Anna Castro )....
