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Informationen zum Autor Chris Calladine is Professor of Structural Mechanics at the University of Cambridge. In addition to researching aspects of structural engineering, he has applied the methods of structural mechanics to the study of flagella and DNA. Horace Drew solved several of the first DNA crystal X-ray structures with Richard Dickerson at Caltech, and subsequently spent five years researching DNA and chromosome structures with Aaron Klug at the MRC Laboratory of Molecular Biology in Cambridge, UK He now lives in Australia and is a Principle Research Scientist at the CSIRO Division of Biomolecular Engineering in Sydney. Ben Luisi works in the Department of Biochemistry at the University of Cambridge, where he has an appointment as professor of structural biology. He and his colleagues study the structure and mechanism of efflux pumps and the riboregulatory machinery that help to control the expression of the pumps and other complex systems in bacteria. Klappentext The functional properties of any molecule are directly related to! and affected by! its structure. This is especially true for DNA! the molecular that carries the code for all life on earth. The third edition of Understanding DNA has been entirely revised and updated! and expanded to cover new advances in our understanding. It explains! step by step! how DNA forms specific structures! the nature of these structures and how they fundamentally affect the biological processes of transcription and replication. Written in a clear! concise and lively fashion! Understanding DNA is essential reading for all molecular biology! biochemistry and genetics students! to newcomers to the field from other areas such as chemistry or physics! and even for seasoned researchers! who really want to understand DNA. * Describes the basic units of DNA and how these form the double helix! and the various types of DNA double helix * Outlines the methods used to study DNA structure * Contains over 130 illustrations! some in full color! as well as exercises and further readings to stimulate student comprehension Um halb sechs abends die Nachricht, über das Telefon, durchdie Schwester: wie mich dann, kaum habe ich das Licht darüberangemacht, mein Blick dreifach im dreigeteilten Spiegel trifft,während darunter aus dem Hahn das Wasser kalt über meineHände läuft und die Kälte in meine Arme kriecht, in die Schultern, von da in Brust und Bauch und Lenden fließt,und wie ich, als mein Pinkeldrang nicht mehr zu unterdrückenist, meine Hose öffne und den Strahl, nachdem ich den Wasserhahngeschlossen habe, ins Waschbecken lenke und dort genau übermeine Hände, dabei wieder das Treffen der Blicke des Blicks,links und Mitte und rechts. Wie ich mir noch Pullover und Oberhemdausziehe und das Unterhemd, mit nassen Händen über meineBrust fahre, die Warzen fest in die Rippen drücke: ein Aufbegehrengegen die Stummheit. Aus der Küche das gleichmäßigeSchlingern der Waschmaschine, wie die Katzen auf der Badezimmerschwellehocken und mich von unten her anschauen, als warteten sie darauf,was gleich kommt. Wie ich mir die Hose wieder zuknöpfe undmich, während ich tief Atem hole, mit beiden Händengegen das Waschbecken stemme und den Mund öffne: Schreienund Brüllen, nur noch Maul, dreifach vom Spiegel zurückgeworfen,anhaltender Ton bis zum Wimmern, und die Katzen, obschon sie diesenAusbruch erwartet haben, sind erschrocken auf und davon. Wieich dann wieder Unterhemd und Oberhemd anlege, die rote ... . Zusammenfassung The functional properties of any molecule are directly related to! and affected by! its structure. This is especially true for DNA. This edition explains! step by step! how DNA forms specific structures! the nature of these structures and how they fundamentally affect the biological processes of transcription and replication. Inhaltsverzeichnis An In...
List of contents
An Introduction to Molecular Biology for Non-Scientists
Why a Helix?
Different Kinds of Double Helix
Twisting and Curving
Curving in Three Dimensions
DNA Supercoiling
The Assembly of DNA intor Chromosomes
Specific DNA-Protein Interactions
Methods Used to Study the Structure of DNA
DNA in Disease, Diagnostics and Medicine
Cytosine Methylation and DNA Epigenetics
Appendix
1: Notes on the Derivation of Some Technical Terms
2: The Chemical Theory of Base-stacking Interactions in DNA
3: How to modify Gene Expression by means of Anti-sense Oligonucleotides, Ribozymes or si-RNA
Report
Praise for previous editions:
"Stylish...beautifully crafted, with a logical step-by-step approach to the subject. A book from which the advanced undergraduate will benefit and which will also generate a refreshing perspective for experts" --NATURE
"Understanding DNA is a great book that will surely prove to be a valuable teaching tool." --THE BIOCHEMIST
"A systematic and comprehensive analysis of the structure of DNA from a wonderfully fresh perspective." --TRENDS IN GENETICS
