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Never in history has there been greater hope that novel experimental therapies can support significant restoration of brain function. The field of restorative therapies in Parkinsons disease has passed the initial phase of pioneering experimental and clinical trials. There still does not exist restorative therapy that can be applied in large numbers of patients, but the initial trials have provided us with fundamental insight into the potential for plasticity in the diseased brain. This book gives an overview of the current state-of-the-art research for brain repair, what the challenges are and an indication of what research can provide for the next generation of people with Parkinsons disease.
List of contents
Restorative Therapies in a Historical Perspective.- Ethical Issues in the Approaches of Restorative Therapies for Parkinson's Disease.- Evolution of Parkinson's Disease and Treatment Requirements.- What New Treatments are Needed and the Role of Striatal Grafting.- Clinical Trial Design Issues.- Lessons Learnt from Early Clinical Neural Grafting in Parkinson's Disease.- Fetal Nigral Transplantation as a Therapy for Parkinsons Disease.- Imaging of the Parkinsonian Brain in Relation to Restorative Therapy.- Important Aspects of Surgical Methodology for Transplantation in Parkinsons Disease.- Histopathological and Clinical Criteria for Analyzing Transplanted Human Dopamine Cells in Parkinson's Disease.- Dyskinesias and Neural Grafting in Parkinson's Disease.- Porcine Neural Xenotransplantation: Current Status.- Adult-Derived Stem Cells for Transplantation in Parkinson's Disease.- Embryonic Stem Cells for Grafting in Parkinson's Disease.- Delivery of GDNF For Parkinson's Disease: Transition of a Neuroprotective Treatment Strategy from Basic Sciences to Clinical Application.- Genetically Modified Cells as a Source for Grafting in Parkinson'se Disease.- In Vivo Gene Therapy as a Potential Treatment for Parkinson's Disease.
