Stability of Protein Pharmaceuticals - Part B: In Vivo Pathways of Degradation and Strategies for Protein Stabilization

Part B explores protein degradation occuring in vivo during protein synthesis in cells, examines the isolation and purification of proteins, details protein use in organisms, and reviews techniques to enhance protein stability.

List of contents

Improper Glycosylation and the Cellular Editing of Nascent Proteins; D.A. Cumming. Protein Aggregation In Vivo; R. Wetzel. Pathways of Intracellular Protein Degradation in Eukaryotic Cells; T.S. Olson, et al. Effects of Aging on Proteins; R.W. Gracy. Engineering Dramatic Increases in the Stability of Subtilisin; P.N. Bryan. Increased Stability of Mutant Forms of Yeast Cytochrome c; D.R. Hickey, et al. Introduction to Formulation of Protein Pharmaceuticals; M.A. Hanson, S.K.E. Rouan. PEG Modified Proteins; G.E. Francis, et al. Stabilization of Protein Structure by Solvent Additives; S.N. Timasheff. Heat-Shock Proteins and their Potential Uses for Pharmaceutical Protein Production in Microorganisms; J.M. McCoy. Index.

Summary

Part B explores protein degradation occuring in vivo during protein synthesis in cells, examines the isolation and purification of proteins, details protein use in organisms, and reviews techniques to enhance protein stability.

Report

`Offers the most comprehensive treatment to date of the various degradation pathways of pharmaceutical proteins....The two-volume set is an essential reference for pharmaceutical scientists.'
BioPharm

Product details

• Authors: Tim J. Ahern, Mark C. Manning
• Assisted by: Tim J Ahern (Editor), Tim J. Ahern (Editor), C Manning (Editor), C Manning (Editor), Ti J Ahern (Editor), Tim J Ahern (Editor), Mark C Manning (Editor), Mark C. Manning (Editor)
• Publisher: Springer, Berlin
• Languages: English
• Product format: Hardback
• Released: 30.06.2009
• EAN: 9780306441530
• ISBN: 978-0-306-44153-0
• No. of pages: 328
• Dimensions: 152 mm x 229 mm x 22 mm
• Weight: 680 g
• Illustrations: XXVI, 328 p.
• Series: Pharmaceutical Biotechnology; Pharmaceutical Biotechnology
• Subject: Natural sciences, medicine, IT, technology > Medicine > Non-clinical medicine