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Our understanding of inflammation has increased rapidly in recent years, due in large part to the impact of molecular biology and gene identification and cloning. This book brings together ideas from a number of different biochemical disciplines which are frequently not integrated.
The first chapter gives a visual overview of the subject; the remaining chapters are organized into three themes: the affector molecules, the regulatory components and the processes of inflammation itself.
This book is essential reading for the busy physician or pathologist who wants to be up-to-date with the latest developments in immunology as they affect the diagnosis and treatment of many conditions.
List of contents
1 An overview of the inf lammatory response.- 2 The complement system and inflammation.- 3 The kinin system: current concepts and perspectives.- 4 Role of cellular proteinases and their protein inhibitors in inflammation.- 5 Eicosanoids (prostaglandins and leukotrienes).- 6 The role of toxic oxygen species in inflammation with special reference to DNA damage.- 7 Glucocorticoids and lipocortin.- 8 Platelet activating factor and cytokine feedback regulation ofendothelial integrity: implications for the treatment of inflammatory disease.- 9 A role for neuropeptides in inflammation.- 10 Interleukin 1 as an inflammatory mediator.- 11 Tumour necrosis factor (TNF) and inflammation.- 12 Interleukin 6: a consequence of inflammation.- 13 The acute phase response.- 14 The role of leukocyte chemotaxis in inflammation.
Summary
Our understanding of inflammation has increased rapidly in recent years, due in large part to the impact of molecular biology and gene identification and cloning. This book brings together ideas from a number of different biochemical disciplines which are frequently not integrated.
The first chapter gives a visual overview of the subject; the remaining chapters are organized into three themes: the affector molecules, the regulatory components and the processes of inflammation itself.
This book is essential reading for the busy physician or pathologist who wants to be up-to-date with the latest developments in immunology as they affect the diagnosis and treatment of many conditions.
