Metabolism At A Glance

Klappentext Metabolism at a Glance is a complete review course of metabolism in health and disease and offers a unique approach to the study of this difficult discipline.Metabolism is a complicated subject involving complex molecules and interrelated pathways. These metabolic pathways are usually taught separately with the result that the student develops a detailed but compartmentalised approach to metabolism and frequently fails to see the overall picture and its physiological significance.Using the at a Glance format! the book takes the student through a complete course in intermediary metabolism in an integrated manner. The same chart is repeated throughout the book with the individual pathway under study highlighted.The book is an ideal text for introductory biochemistry courses and has established itself as an enormously popular book amongst lecturers and students alike. This third edition is fully updated and includes five new chapters:1. Metabolic Channelling2. Glucose homeostasis and Reye's Disease3. Pentose phosphate pathway and the prodcution of NADPH4. Tryptophan metabolism in health and disease5. Tyrosine metabolism in health and disease Inhaltsverzeichnis Foreword. Preface. 1 Introduction to Metabolic Pathways. 2 Biosynthesis of ATP! part I. 3 Biosynthesis of ATP! part II. 4 The oxidation of cytosolic NADH + H+. 5 Metabolism of glucose to give energy. 6 Metabolism of one molecule of glucose to form 38 molecules of ATP. 7 Metabolism of glucose to glycogen. 8 Anaerobic metabolism of glucose and glycogen to yield energy as ATP. 9 2!3 Bisphosphoglycerate and the red blood cell. 10 Metabolism of glucose to fat (triacylglycerol). 11 Metabolism of glucose to fatty acids and triacylglycerol. 12 The pentose phosphate pathway and the production of NADPH. 13 The pyruvate/malate cycle and the production of NADPH. 14 Mammals cannot synthesis glucose from fatty acids. 15 Metabolism of triacylglycerol to provide energy as ATP. 16 Glycogen metabolism part I. 17 Glycogen metabolism part II. 18 Glycogen metabolism part III: regulation of glycogen breakdown. 19 Glycogen metabolism part IV : regulation of glycogen biosynthesis. 20 Regulation of glycolysis. 21 Glycolysis and the pentose phosphate pathway in the liver in the fed state. 22 Glycolysis in skeletal muscle; biochemistry of sport and excerise. 23 Regulation of gluconeogenesis. 24 Regulation of the Krebs cycle. 25 Regulation of fatty acid oxidation part I. 26 Regulation of fatty acid oxidation part II. 27 The ketone bodies. 28 Ketone body utilisation. 29 Beta-Oxidation of unsaturated fatty acids. 30 Peroxisomal Beta-oxidation. 31 Elongation and desaturation of fatty acids. 32 Cholestrerol! bile acids and the steroid hormones. 33 The ornithine cycle for the production of urea. 34 Metabolic Channelling. 35 Biosynthesis of the non-essential amino acids. 36 Catabolism of amino acids. 37 Catabolism of amino acids. 38 Metabolism of amino acids to glucose in starvation and during the period immediately after re-feeding. 39 Metabolism of protein to fat. 40 Disorders of amino acid metabolism. 41 Tyrosine metabolism in health and disease. 42 Tyrosine metabolism. 43 Amino acid metabolism! folate metabolism and the 1-carbon pool part I. 44 Amino acid metabolism! folate metabolism and the 1-carbon pool part II. 45 Porphyrin metabolism! heam and the bile pigments. 46 Metabolism of ethanol. 47 Sorbitol! galactitol! glucaronate and xylitol. 48 Fructose metabolism. 49 Glucose homeostasis: Reye's syndrome. 50 Diabetes I: insulin-stimulated glycogen synthesis. 51 Diabetes II: metabolic changes in Type I diabetes. 52 Diabetes III: Type I diabetes! type II diabetes! MODY and pancreatic Beta-cell metabolism. 53 Diabetes IV: type II diabetes and insulin resistance in muscle. 54 Diabetes V: type II diabetes and insulin resistance in adipose tissue. 55 Diabetes VI: type II diabetes and insulin resistance in liver. Index. ...

List of contents

Foreword 8

Preface 9

1 Introduction to metabolic pathways 10

2 Biosynthesis of ATP I: ATP, the molecule that powersmetabolism 12

3 Biosynthesis of ATP II: mitochondrial respiratory cheln 14

4 The oxidation of cytosolic NADH: the malate/aspartateshuttle and the glycerol phosphate shuttle 16

5 Metabolism of glucose to provide energy 18

6 Metabolism of one molecule of glucose yields 31 (or should itbe 38?) molecules of ATP 20

7 Metabolism of glucose to glycogen 22

8 Anaerobic metabolism of glucose and glycogen to yield energyas ATP 24

9 2,3-Blsphosphoglycerate (2,3-BPG) and the red blood cell26

10 Metabolism of glucose to fat (trlacylglycerol) 28

11 Metabolism of glucose to fatty acids and trlacylglycerol30

12 The pentose phosphate pathway: the production of NADPH andreduced glutathione 32

13 Tha pyruvate/malate cycle and the production of NADPH 34

14 Mammals cannot synthesize glucose from fatty acids 36

15 Metabolism of trlacylglycerol to provide energy as ATP 38

16 Glycogen metabolism I 40

17 Glycogen metabolism II 42

18 Glycogen metabolism III: regulation of glycogen breakdown44

19 Glycogen metabolism IV: regulation of glycogen synthesis46

20 Regulation of glycolysis: overview exemplified by glycolysisIn cardiac muscle 48

21 Glycolysis and the pentose phosphate pathway collaborate Inliver to make fat 50

22 Glycolysis In skeletal muscle: biochemistry of sport andexercise 52

23 Regulation of gluconeogenesis 54

24 Regulation of Krebs cycle 56

25 Regulation of fatty acid oxidation: mobilization of fattyacids from storage In adipose tissue 56

26 Fatty acid oxidation and the carnitine shuttle 60

27 The ketone bodies 62

28 Ketone body utilization 64

28 II-Oxidation of unsaturated fatty acids 66

30 Peroxisomal II-oxidation 66

31 Elongation and desaturation of fatty acids 70

32 Cholesterol, bile acids and the steroid hormones 72

33 The omlthlne cycle for the production of urea: the ureacycle 74

34 Metabolic chennelllng: enzymes are organized to enablechennelling of metabolic Intermediate. 76

35 Biosynthesis of the non-essential amino acids 78

36 Catabolism of amino acids I 80

37 Catabolism of amino acids II 82

38 Metabolism of amino acids to glucose in starvatlon and duringthe period Immediately after refeeding 84

39 Metabolism of protein to fat 86

40 Disorders of amino acid metabolism 88

41 Phenylalanine and tyresine metabolism 90

42 Tryptophan metabolism: the biosynthesis of NAD+, serotoninand melatonin 92

43 Amino acid metabolism, folate metabolism and the i-carbonpool I: purine biosynthesis 94

44 Amino acid metabolism, folate metabolism and the i-carbonpool II: pyrimidine biosynthesis 96

45 Porphyrin metabolism, haem and the bile pigments 98

46 Metabolism of ethanol 100

47 Sorbitol, galactitol, glucuronate and xylltol 102

48 Fructose metabolism 104

49 Metabolic pathways in fasting liver and their disorder inReye s syndrome 106

50 Diabetes I: insulin-stimulated glucose uptake into cells andglycogen synthesis - signal transduction 1 08

51 Diabetes II: metabolic changes in Type 1 diabetes 110

52 Diabetes III: Type 1 diabetes, Type 2 diabetes, MODY andpancreatic poeell metabolism 112

53 Diabetes IV: Type 2 diabetes and insulin resistance in muscle114

54 Diabetes V: Type 2 diabetes and insulin resistance in adiposetissue 116

55 Diabetes VI: Type 2 diabetes and insulin resistance in liver118

Index 121

Report

On the first edition:

"...a highly comprehensive set of notes and pathway mapsconcentrated exclusively on metabolism. If you are after an easygoing metabolism book for revision or as a good reference guide,this would be the ideal choice, as it is not too daunting to readand had plenty of well-organised pathway maps to keep you busy.This is especially useful for first year medics as part of theirfoundation study revision"

Leech y Gelen, University of Wales College ofMedicine"

"The book is easy to follow as the salient features of eachmetabolic pathway are highlighted on a detailed background map.This aided the introduction of the metabolic concepts in a verywell-integrated fashion. The chapters on the more medical aspectswill appeal especially to medical students as they correlate neatlythe basic biochemical principles with the development of somemetabolic diseases such as glycogen storage diseases."

Biochemistry and Molecular Biology Education

Product details

• Authors: J. G. Salway, Jack Salway
• Publisher: Blackwell Scientific Publishers Ltd
• Languages: English
• Product format: Paperback / Softback
• Released: 31.12.2003
• EAN: 9781405107167
• ISBN: 978-1-4051-0716-7
• Dimensions: 290 mm x 344 mm x 10 mm
• Series: At a Glance S.; At a Glance (Blackwell); At a Glance (Blackwell)
• Subject: Natural sciences, medicine, IT, technology > Medicine > Clinical medicine