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The design of efficient syntheses of medicinal agents is one of the prime goals of the process chemist in the pharmaceutical industry. The expanding list of metal-mediated reactions has had a major impact on this endeavor over the last two decades. This volume will highlight some of the areas of organometallic chemistry that have played a particularly important role in development. The chapters are written by chemists who work in the process groups of major pharmaceutical companies and fine chemical manufacturers. Having demonstrated the power of organometallics in their processes the authors herein expand upon their experiences with examples from the literature as reported by process groups within the industry. The chapters are organized either by the application of a particular metal or reaction class. Removal of the residual metal(s) from the isolated active pharmaceutical ingredient (API) is key to the release of the material for human consumption, and hence, is reviewed here as well. This volume of Topics in Organometallic Chemistry is presented to offer a representative cross section of organometallic applications in the pharmaceutical industry as well as to give an appreciation for the creativity possible in process chemistry.
List of contents
G.G. Wu, M. Huang: Organolithium in Asymmetric Processes.- D.L. Hughes: Applications of Organotitanium Reagents.- K. Sumi, H. Kumobayashi: Rhodium/Ruthenium Applications.- A.J. Delmonte, E.D. Dowdy and D.J. Watson: Development of Transition Metal-Mediated Cyclopropanation Reactions.- J.F. Larrow, E.N. Jacobsen: Asymmetric Processes Catalyzed by Chiral (Salen)Metal Complexes.- S.J. Mehrman, A.F. Abdel-Magid, C.A. Maryanoff and B.P. Medaer: Non-Salen Metal-Catalyzed Asymmetric Dihydroxylation and Asymmetric Aminohydroxylation of Alkenes. Practical Applications and Recent Advances.- M. Prashad: Palladium-Catalyzed Heck Arylations in the Synthesis of Active Pharmaceutical Ingredients.- A.O. King, N. Yasuda: Palladium-Catalyzed Cross-Coupling Reactions in the Synthesis of Pharmaceuticals.- J. Kant: Stereospecific Introduction of Cephalosporin Side Chains Employing Transition Metal Complexes.- J.T. Bien, G.C. Lane and M.R. Oberholzer: Removal of Metals from Process Streams: Methodologies and Applications
Summary
The design of efficient syntheses of medicinal agents is one of the prime goals of the process chemist in the pharmaceutical industry. The expanding list of metal-mediated reactions has had a major impact on this endeavor over the last two decades. This volume will highlight some of the areas of organometallic chemistry that have played a particularly important role in development. The chapters are written by chemists who work in the process groups of major pharmaceutical companies and fine chemical manufacturers. Having demonstrated the power of organometallics in their processes the authors herein expand upon their experiences with examples from the literature as reported by process groups within the industry. The chapters are organized either by the application of a particular metal or reaction class. Removal of the residual metal(s) from the isolated active pharmaceutical ingredient (API) is key to the release of the material for human consumption, and hence, is reviewed here as well. This volume of Topics in Organometallic Chemistry is presented to offer a representative cross section of organometallic applications in the pharmaceutical industry as well as to give an appreciation for the creativity possible in process chemistry.
Additional text
From the reviews:
From "Angewandte Chemie", Vol. 44, Issue 3, pp. 359-360
"Within the book’s 295 pages, consisting of ten important and well-chosen articles, every reader concerned with the subject is sure to quickly find material relevant to his or her special interests."
"The use of organometallic compounds in chemical process development in the pharmaceutical, agricultural, and fine chemical industries is the focus of the volume. … Overall, the quality and layout of the drawings are quite good, which gives the book high readability. There is also a cumulative author index … . it is one of growing importance and visibility in the organic chemistry community. … the information and underlying message would be quite beneficial for academicians to experience and appreciate." (Kim Albizati, Journal of the American Chemical Society, Vol. 127 (6), 2005)
"It is impossible to imagine synthetic work without the help of organometallic transformations. …The individual chapters of the book can be regarded as giving a snapshot of the present state of progress in this technology. … every reader concerned with the subject is sure to quickly find material relevant to his or her special interests. … it should certainly be available in the libraries of companies that are concerned with this type of chemistry. It can also serve as a quick source of useful information for university teachers … ." (Martin Bröring, Angewandte Chemie International Edition, Vol. 44 (3), 2005)
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From the reviews:
From "Angewandte Chemie", Vol. 44, Issue 3, pp. 359-360
"Within the book's 295 pages, consisting of ten important and well-chosen articles, every reader concerned with the subject is sure to quickly find material relevant to his or her special interests."
"The use of organometallic compounds in chemical process development in the pharmaceutical, agricultural, and fine chemical industries is the focus of the volume. ... Overall, the quality and layout of the drawings are quite good, which gives the book high readability. There is also a cumulative author index ... . it is one of growing importance and visibility in the organic chemistry community. ... the information and underlying message would be quite beneficial for academicians to experience and appreciate." (Kim Albizati, Journal of the American Chemical Society, Vol. 127 (6), 2005)
"It is impossible to imagine synthetic work without the help of organometallic transformations. ...The individual chapters of the book can be regarded as giving a snapshot of the present state of progress in this technology. ... every reader concerned with the subject is sure to quickly find material relevant to his or her special interests. ... it should certainly be available in the libraries of companies that are concerned with this type of chemistry. It can also serve as a quick source of useful information for university teachers ... ." (Martin Bröring, Angewandte Chemie International Edition, Vol. 44 (3), 2005)
