Functional Tissue Engineering

Tissue engineering is an exciting new field at the interface of engineering and - ology that uses implanted cells, scaffolds, DNA, proteins, protein fragments, and inductive molecules to repair or replace injured or diseased tissues and organs. Tremendous progress in biological and biomaterial aspects of this field have been accomplished to date, and several engineered tissues are now being used clinically. However, tissue engineers face major challenges in repairing or repl- ing tissues that serve a predominantly biomechanical function. To meet this challenge, the United States National Committee on Biomech- ics in 1998 adopted a new paradigm termed functional tissue engineering (FTE) to emphasize the importance of biomechanical considerations in the design and - velopment of cell and matrix-based implants for soft and hard tissue repair. Functional tissue engineering represents a relevant and exciting new discipline in the field of tissue engineering. Since many tissues, such as those of the muscu- skeletal, cardiovascular, and dental systems, are accustomed to being mecha- cally challenged, tissue-engineered constructs used to replace these tissues after injury or disease must certainly do the same. Of course, tissue engineers must also attempt to return normal biological activity in order for the construct to truly - tegrate with the surrounding tissues. Thus, the term functional can have many meanings, such as restoration of metabolic function. The primary focus of this text is on the role of biomechanical function in tissue engineering.

List of contents

The Functional Properties of Native Tissues.- How Does Nature Build a Tissue?.- Ligament Healing: Present Status and the Future of Functional Tissue Engineering.- Native Properties of Cardiovascular Tissues: Guidelines for Functional Tissue Engineering.- Functional Properties of Native Articular Cartilage.- Excitability and Contractility of Skeletal Muscle: Measurements and Interpretations.- Functional Requirements of Engineered Tissues.- Functional Requirements for the Engineering of a Blood Vessel Substitute.- In Vivo Force and Strain of Tendon, Ligament, and Capsule.- Requirements for Biological Replacement of the Articular Cartilage at the Knee Joint.- Functional Requirements: Cartilage.- Design Parameters for Tissue Engineering.- Design Parameters For Functional Tissue Engineering.- Tissue Engineering a Heart: Critical Issues.- Design Parameters for Engineering Bone Regeneration.- Tissue Engineering of Bone: The Potential Use of Gene Therapy for Difficult Bone Loss Problems.- Engineered Skeletal Muscle: Functional Tissues, Organs, and Interfaces.- Bioengineering the Growth of Articular Cartilage.- Assessment of Junction in Engineered Tissues.- Functional Tissue Engineering: Assessment of Function in Tendon and Ligament Repair.- The Role of Mechanical Forces in Tissue Engineering of Articular Cartilage.- Biomechanics of Native and Engineered Heart Valve Tissues.- Assessment of Function in Tissue-Engineered Vascular Grafts.- Assessment of the Performance of Engineered Tissues in Humans Requires the Development of Highly Sensitive and Quantitative Noninvasive Outcome Measures.- Cell-Matrix Interactions in Functional Tissue Engineering.- Functional Tissue Engineering and the Role of Biomechanical Signaling in Articular Cartilage Repair.- Regulation of Cellular Responseto Mechanical Signals by Matrix Design.- Artificial Soft Tissue Fabrication from Cell-Contracted Biopolymers.- Cytomechanics: Signaling to Mechanical Load in Connective Tissue Cells and Its Role in Tissue Engineering.- Bioreactors and the Role of Biophysical Stimuli in Tissue Engineering.- The Role of Biomechanics in Analysis of Cardiovascular Diseases: Regulation of the Fluid Shear Response by Inflammatory Mediators.- A Full Spectrum of Functional Tissue-Engineered Blood Vessels: From Macroscopic to Microscopic.- Engineering Functional Cartilage and Cardiac Tissue: In vitro Culture Parameters.- Tissue Engineering Skeletal Muscle.- Regulatory and Clinical Tissues in Tissue Engineering.- From Concept Toward the Clinic: Preclinical Evaluation of Tissue-Engineered Constructs.- Trends in the FDA.

Summary

Tissue engineering is an exciting new field at the interface of engineering and - ology that uses implanted cells, scaffolds, DNA, proteins, protein fragments, and inductive molecules to repair or replace injured or diseased tissues and organs. Tremendous progress in biological and biomaterial aspects of this field have been accomplished to date, and several engineered tissues are now being used clinically. However, tissue engineers face major challenges in repairing or repl- ing tissues that serve a predominantly biomechanical function. To meet this challenge, the United States National Committee on Biomech- ics in 1998 adopted a new paradigm termed functional tissue engineering (FTE) to emphasize the importance of biomechanical considerations in the design and - velopment of cell and matrix-based implants for soft and hard tissue repair. Functional tissue engineering represents a relevant and exciting new discipline in the field of tissue engineering. Since many tissues, such as those of the muscu- skeletal, cardiovascular, and dental systems, are accustomed to being mecha- cally challenged, tissue-engineered constructs used to replace these tissues after injury or disease must certainly do the same. Of course, tissue engineers must also attempt to return normal biological activity in order for the construct to truly - tegrate with the surrounding tissues. Thus, the term functional can have many meanings, such as restoration of metabolic function. The primary focus of this text is on the role of biomechanical function in tissue engineering.

Additional text

From the reviews:

"Functional Tissue Engineering is a useful compilation of research by contributors involved in developing tissues … . It is not easy to extract a decent book from a conference, but the editors have done a very good job … . it will be an invaluable source for those starting a PhD … . I recommend it to those embarking on or already involved in engineering structural tissues. … The chapters are well written … . The book is clearly focused to encompass practical issues, such as the need to create appropriate biomechanical environments … ." (Sheila MacNeil, Materials Today, July/August, 2005)

Report

From the reviews:

"Functional Tissue Engineering is a useful compilation of research by contributors involved in developing tissues ... . It is not easy to extract a decent book from a conference, but the editors have done a very good job ... . it will be an invaluable source for those starting a PhD ... . I recommend it to those embarking on or already involved in engineering structural tissues. ... The chapters are well written ... . The book is clearly focused to encompass practical issues, such as the need to create appropriate biomechanical environments ... ." (Sheila MacNeil, Materials Today, July/August, 2005)

Product details

• Assisted by: Steven A Goldstein et al (Editor), David L. Butler (Editor), Steven A Goldstein (Editor), Steven A. Goldstein (Editor), Farshid Guilak (Editor), Davi L Butler (Editor), David L Butler (Editor), David Mooney (Editor)
• Publisher: Springer, Berlin
• Languages: English
• Product format: Hardback
• Released: 17.07.2003
• EAN: 9780387955537
• ISBN: 978-0-387-95553-7
• No. of pages: 426
• Weight: 960 g
• Illustrations: XVI, 426 p.
• Subjects: Natural sciences, medicine, IT, technology > Biology > Genetics, genetic engineering; C, Orthopedics, Orthopaedics, Biomedical and Life Sciences, Surgical orthopaedics & fractures, Biomedical Engineering and Bioengineering, Biomedical engineering, Cell Biology