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This book meets the long-awaited need for a comprehensive overview of the biological role of HDLs. Edited by one of the pioneers in HDL and cholesterol research, this monograph summarizes current knowledge on HDL turnover, regulation and physiology. Clearly structured, the various sections cover HDL structure, formation, secretion and removal, as well as plasma metabolic factors. The biological activities and clinical aspects are equally discussed, as is the impact of HDL on common diseases and their prevention.
List of contents
HDL STRUCTRE
Apolipoprotein A1
Apolipoprotein A2
Apolipoprotein E
Apolipoprotein M
HDL PLASMA METABOLIC FACTORS
ABC Transporters
Apo A1 Recycling and LCAT
CETP, PLTP and Enothelial Lipase
Phospholipid Transfer Proteins
HDL Remodelling by Lipases
HDL FORMATION, SECRETION, REMOVAL
Apo A1 Synthesis and Secretion
Mouse Models of HDL Synthesis and Secretion
Hepatic and Renal HDL Receptors
BIOLOGICAL ACTIVITIES OF HDL
HDL and Inflammation
HDL and Exercise
HDL and Endothelium
Apo A1 and Nutrition
Nutrition and HDL Speciation
CLINICAL ASPECTS OF HDL
HDL in Metabolic Syndromes
HDL and Genetics
HDL and Atherosclerosis
HDL-raising Drugs
About the author
Christopher J. Fielding is Neider Professor of Cardiovascular Physiology at the University of California at San Francisco (UCSF). He graduated from University College in London (UK) where he also received his PhD. After appointments at Oxford University and at the University of Chicago, he joined the faculty at UCSF in 1971, being appointed full professor in 1985. Professor Fielding's main research interest is in the trafficking of cholesterol, its regulation and its role in signal transduction.
Summary
This book meets the long-awaited need for a comprehensive overview of the biological role of HDLs. Edited by one of the pioneers in HDL and cholesterol research, this monograph summarizes current knowledge on HDL turnover, regulation and physiology. Clearly structured, the various sections cover HDL structure, formation, secretion and removal, as well as plasma metabolic factors. The biological activities and clinical aspects are equally discussed, as is the impact of HDL on common diseases and their prevention.
