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Informationen zum Autor Dr Daniel Lednicer 's career in both the private and public sectors has been devoted to the search for new therapeutic agents. Dr. Lednicer spent two decades at the bench as a chemist at the Upjohn Company. Following that, he served as director of chemical research at Mead Johnson, director of pharmaceutical sciences at Adria Laboratories, and pharmaceutical manager at Analytical Biochemistry Laboratories. Most recently, he was a project officer at the National Cancer Institute. Dr Lednicer is the acclaimed author of several books on drug synthesis and discovery, including 7 volumes of the series Organic Chemistry of Drug Synthesis (Wiley US). Klappentext The term steroid has become virtually synonymous with drug abuse in sport to the majority of the public. However these steroids - androgens - actually comprise only a single relatively small class of biologically active steroids, and are overshadowed by a large collection of compounds, a sizeable number of which are commercial drugs that share the same structural carbon skeleton. The development of these drugs has led to a large body of organic chemistry often denoted 'Steroid Chemistry'. Steroid Chemistry at a Glance provides a concise overview of the main principles, biological activity, chemical synthesis and reactions of steroid chemistry. Topics covered include: history, isolation and structure determination of steroids steroid nomenclature and stereochemistry natural sources of steroids estranes gonanes (19-nor steroids) androstanes progestins corticosteroids heterocyclic steroids Based on the highly successful and student friendly 'at a glance' approach, Steroid Chemistry at a Glance provides students with a resource with which they can quickly, concisely and confidently acquire, regularly review and revise the basic facts that underpin the properties, synthesis and reactions of this important class of natural product-derived compounds. It will also serve as a handy bench reference for postgraduates and professional chemists. Zusammenfassung Androgen steroids have become virtually synonymous with drug abuse in sports but are in reality overshadowed by a large collection of compounds, which are commercial drugs that share the same structural carbon skeleton. Steroid Chemistry At A Glance provides a concise overview of the main principles and reactions of steroid chemistry. Inhaltsverzeichnis Preface. Introduction. 1 Steroids: a Brief History. 1.1 Structure Determination. 1.1.1 Cholesterol and Cholic Acid. 1.1.2 The Sex Steroids. 1.1.3 Corticosteroids. 2 Sources of Steroids. 2.1 Biosynthesis. 2.2 Commercial Steroid Starting Materials. 2.2.1 Diosgenin. 2.2.2 Soybean Sterols. 3 Estranes: Steroids in Which Ring A is Aromatic. 3.1 Biological Activity. 3.2 Sources of Estranes. 3.2.1 From Androstanes. 3.2.2 Estrogens by Total Synthesis. 3.3 Chemical Reactions of Estranes. 3.3.1 Aromatic A-ring Reactions. 3.3.2 Modifications on Ring B. 3.3.3 Modifications on Ring C. 3.3.4 Modifications on Ring D. 3.4. Some Drugs Based on Estranes. 4 Gonanes or 19-nor-Steroids. 4.1 Preparation of Gonane Starting Materials. 4.1.1 Birch Reduction. 4.1.2 Synthesis by Sequential Annulation Reactions. 4.2 Anabolic-Androgenic Gonanes. 4.2.1 Biological Activity. 4.2.2 Synthesis of 19-Norandrogens. 4.3 Progestational Gonanes. 4.3.1 Biological Activity. 4.3.2 Preparation of 19-Norprogestins. 4.4 Some Drugs Based on Gonanes. 4.4.1 Androgenic-Anabolic Agents. 4.4.2 Progestins. 4.4.3 Progestin Antagonists. 5 Androstanes, C19 Steroids and Their Derivatives. 5.1 Biological Activity. 5.2 Sources of Andros...
