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Informationen zum Autor Mark read chemistry at the University of Durham, completed his DPhil with Professor S.G. Davies at the University of Oxford, and then moved to The Scripps Research Institute to work with Professor K.C. Nicolaou as a NATO postdoctoral fellow. Mark joined Pfizer in the UK as a medicinal chemist in 1996 and since then has assumed a number of roles of increasing responsibility. Mark is currently the Head of Medicinal Chemistry for Pfizer in Sandwich. Mark has broad interests in medicinal chemistry and is an author or inventor on over 50 publications and patents. Klappentext Chemical biology is an emerging field at the interface between chemistry and biology that utilises the tools and techniques of chemical synthesis to study and influence biological systems. Recent developments in this area have great potential in addressing drug discovery productivity challenges. For example, chemical biology studies have already led to the identification of novel targets with exciting therapeutic potential and it is clear that the field will prove a key enabler of improved target discovery in the future. Moreover, the precise synthetic manipulation of biological molecules applicable to many chemical biology approaches is now fuelling a new wave of chemically-modified biologics, 'chemologics', with unique properties. In these, and many other ways, chemical biology is beginning to emerge as a key discipline within 21st century drug discovery and the purpose of this book is to highlight a number of the most important developments. The chapters illustrate the powerful role that chemical genetic and proteomic approaches can play in interrogating biological mechanisms and developing a deeper understanding of how small molecules interact in more complex biological systems. The modulation of stem cell behaviour through small molecules is also discussed and the emerging field of epigenetics. An overview of chemologic approaches includes highlights from the areas of synthetic vaccines and oligonucleotide therapeutics, and additional chapters focus on antibody drug conjugates and DNA-encoded libraries. New Frontiers in Chemical Biology: Enabling Drug Discovery provides a valuable resource for scientists both in industry and academia who are looking to raise their awareness of chemical biology and how it may enable future drug discovery. Zusammenfassung This book highlights the new frontiers in chemical biology and describes their impact and future potential in drug discovery. Inhaltsverzeichnis Chemical Proteomics; Chemical Genetics; Chemical Biology of Post-Translational; Modifications; Chemical Biology of Epigenetics; RNA Interference; Proteolysis Targeting; himeric Molecules (PROTACS); Antibody-Drug Conjugates; Chemologics: New Therapeutics at the Interface of Chemistry and Biology;...
