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The first comprehensive coverage of all facets of the Claisen rearrangement and its variants. This book helps the synthetic chemist to exploit the vst potential of this elegant C-C linking reaction, discusses a wealth of catalytic options, and gives the more theory-minded chemist close insight into the mechanistic aspects of the Claisen rearrangement. It is an extemely valuable source of information and also a ready reference for all organic and catalytic chemists, chemists working with/on organometallics, and chemists in industry.
List of contents
PrefaceTheoretical Aspects of the Claisen RearrangementChorismate Mutase-Catalyzed Claisen RearrangementChiral Metal Complex-Catalyzed Aliphatic Claisen RearrangementAlphabetic and Aromatic Claisen RearrangementMetal-Catalyzed Claisen RearrangementSimple Enolate and Chelate Enolate Claisen RearrangementClaisen-Johnson Orthoester RearrangementThe Meerwein-Eschenmoser Claisen RearrangementThe Carroll RearrangementThio-Claisen RearrangementAza-Claisen Rearrangement
About the author
Martin Hiersemann was born 1966 in Berlin, Germany. He received his Ph.D. in 1995 under the guidance of Johann Mulzer at the Freie Universität Berlin. After postdoctoral stay with Gary A. Molander at the University of Colorado, he started his independent research at the Dresden University of Technology in the fall of 1997. He was a visiting scientist at the University of Tsukuba in the group of Akira Hosomi in 2002, at Harvard University in the group of David A. Evans in 2003 and at the Montana State University with Paul A. Grieco in 2004. His research activities are concerned with the catalysis of sigmatropic rearrangements as well as natural product synthesis.
Udo Nubbemeyer received his Diploma and PhD in the group of Prof. Dr. E. Winterfeldt (University of Hannover) and spent a postdoctoral spell at the Ciba-Geigy Laboratory at the University of Fribourg (Switzerland) with Prof. D. Bellus and Dr. B. Ernst (1989/1990). From 1991 to 1996, he worked on his 'Habilitation' in the group of Prof. Dr. J. Mulzer (Freie Universität Berlin). Then, he passed an assistant lecturer period in Berlin and a temporary professorship at the TU Dresden (1999/2001). Actually, he works as an associate professor at the Johannes Gutenberg-Universität of Mainz. His major topics of interest are olefin synthesis, aza Claisen rearrangements, radical cyclizations, medium-sized rings, total synthesis of natural and pharmaceutically important products, alkaloids, eicosanoids, steroids, and amino acids.
Summary
The first comprehensive coverage of all facets of the Claisen rearrangement and its variants. As such, this book helps synthetic chemists to exploit the vast potential of this elegant C-C linking reaction, discusses a wealth of catalytic options, and gives those more theory-minded chemists a detailed insight into the mechanistic aspects of the Claisen rearrangement. An invaluable source of information and a ready reference for all organic and catalytic chemists, as well as those working with/on organometallics, and in industry.
Report
"...Insgesamt lässt sich The Claisen Rearrangementallen Wissenschaftlern an der Hochschule oder aus der Industrie empfehlen, die sich im weitesten Sinne mit (3,3)-sigmatropen Umlagerungen befassen. Einige Teilkapitel sind auch bestens zur Prüfungsvorbereitung geeignet. Nach fast einem Jahrhundert seit der Entdeckung der Claisen-Umlagerung bietet dieses Buch somit eine gelungene Abhandlung einer bedeitsamen Reaktionsklasse der organischen Chemie."Angewandte Chemie, 10/2007
