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Aging is the progressive decline in biological functions over time. This decline targets macromolecules, cells, tissues and, as a consequence, whole organisms. Despite considerable progress in the development of testable hypothesis concerning aging in an evolutionary context, a unifying theory of the molecular/physiological mechanistic causes of aging has not been reached. In fact, is it not clear to what extent aging is a programmed or stochastic process.
This book takes the reader from unicellular bacterial deterioration via senescence in fungi and worms to aging in rodents and humans, allowing a comparative view on similarities and differences in different genetic model systems. The different model systems are scrutinized in the light of contemporary aging hypothesis, such as the free radical and genomic instability theories.
List of contents
Conditional senescence in prokaryotes.- Aging and mitochondrial dysfunction in the filamentous fungus Podospora anserina.- Mitochondria, metabolism, and aging in yeast.- Yeast as a model for ageing and apoptosis research.- Energy metabolism, anti-oxidant defense and aging in Caenorhabditis elegans.- Do green plants age, and if so, how?.- Mammalian and bird aging, oxygen radicals, and restricted feeding.- Aging and the programmed death phenomena.- The human Werner Syndrome as a model system for aging.- Role of subcytotoxic stress in tissue ageing.
Summary
Aging is the progressive decline in biological functions over time. This decline targets macromolecules, cells, tissues and, as a consequence, whole organisms. Despite considerable progress in the development of testable hypothesis concerning aging in an evolutionary context, a unifying theory of the molecular/physiological mechanistic causes of aging has not been reached. In fact, is it not clear to what extent aging is a programmed or stochastic process.
This book takes the reader from unicellular bacterial deterioration via senescence in fungi and worms to aging in rodents and humans, allowing a comparative view on similarities and differences in different genetic model systems. The different model systems are scrutinized in the light of contemporary aging hypothesis, such as the free radical and genomic instability theories.
