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Informationen zum Autor Debra L. Laskin is the author of Oxidative / Nitrosative Stress and Disease, Volume 1203, published by Wiley. Klappentext This volume features a discussion of recent advances related to the cellular and molecular mechanisms mediating the generation of reactive oxygen and nitrogen species and their role in the pathogenesis of human disease, with a particular focus on the respiratory and cardiovascular systems. The volume brings together contributions from basic and clinical scientists in the field with unique approaches and research efforts.The information presented may help facilitate future collaborative studies that will lead to new insights into the pathogenesis of cardiopulmonary diseases characterized by excessive oxidative and nitrosative stress and may suggest innovative directions for therapeutic intervention.NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas.ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member Zusammenfassung This volume features a discussion of recent advances related to the cellular and molecular mechanisms mediating the generation of reactive oxygen and nitrogen species and their role in the pathogenesis of human disease, with a particular focus on the respiratory and cardiovascular systems. Inhaltsverzeichnis Role of oxidative/nitrosative stress-mediated Bcl-2 regulation in apoptosis and malignant transformation Inflammation precedes the development of human malignant mesotheliomas in a SCID mouse xenograft model The role of iNOS-mediated DNA damage in infection- and asbestos-induced carcinogenesis Regulation of apoptosis through cysteine oxidation : implications for fibrotic lung disease Inhibition of inflammation and carcinogenesis in the lung and colon by tocopherols Reactive oxygen species and [alpha, beta]-unsaturated aldehydes as second messengers in signal transduction Redox signaling in inflammation : interactions of endogenous electrophiles and mitochondria in cardiovascular disease Oxidative stress : acute and progressive lung injury Macrophages, reactive nitrogen species, and lung injury Cigarette smoke-mediated oxidative stress, shear stress, and endothelial dysfunction : role of VEGFR2 Nitric oxide and zinc homeostasis in pulmonary endothelium Inhibition of epithelial sodium channels by respiratory syncytial virus in vitro and in vivo Molecular mechanisms of oxidative stress in airways and lungs with reference to asthma and chronic obstructive pulmonary disease Oxidants and antioxidants in sulfur mustard-induced injury. Potential mechanisms for reduced delivery of nitric oxide to peripheral tissues in diabetes mellitus Acute effects of motor vehicle traffic-related air pollution exposures on measures of oxidative stress in human airways Genetic mechanisms of susceptibility to ozone-induced lung disease Mechanisms of oxidant generation by catalase Redox regulation of responses to hypoxia and NO-cGMP signaling in pulmonary vascular pathophysiology The role of oxidative stress in the pathogenesis and treatment of asthma Oxidative/nitrosative stresses trigger type I diabetes : preventable in streptozotocin rats and detectable in human disease Detection of hydrogen sulfide in plasma and knee-joint synovial fluid from rheumatoid arthritis patients : relation to clinical and laboratory measures of inflammation Vascular oxidative stress and inflammation increase with age : amelioratin...
