Glycomics

Klappentext In the past decade, a tremendous progress in understanding the function of carbohydrates or glycans took place. This progress also starts showing the promise of drug development based on the function of carbohydrates. This critical progress largely owes a development of new methodology to determine a role of a carbohydrate and then develop a method to interfere such biological process, mostly taking a form of protein-carbohydrate interaction. In the current three volumes of Methods in Enzymology focusing on glycomics, readers will appreciate how such discoveries were made and how such methods can be applied for readers¿ own research efforts. Each chapter has been designed so that enough scientific background will be given in each chapter for further development of methods by readers themselves. The books thus should be useful for all levels of scientists starting from the last years of colleges, graduate students, postdoctoral fellows to professors and to all levels of scientists in research institutes including industry. The editor is highly hopeful and confident that these volumes of Methods in Enzymology will contribute to another surge in determining the structure and function of glycans and developing new drugs based on carbohydrate functions. Zusammenfassung A collection focusing on glycomics. It lets readers appreciate how such discoveries were made and how such methods can be applied for readers' own research efforts. It is suitable for different levels of scientists starting from the last years of colleges! graduate students! postdoctoral fellows to professors. Inhaltsverzeichnis Section I. Glycomics 1. Mass spectrometric analysis of acidic oligosaccharides K-H. Khoo 2. Mass Spectrometric Analysis of mutant mice Anne Dell 3. Electrospray mass spectrometry including ESI FTICR-MS Robert Linhardt 4. Mass spectrometric data base for N-glycan and O-glycan H. Narimatsu 5. Mass spectrometric analysis of cancer-associated N-glycans. Shinichiro Nishimura 6. Fucosylation as cancer marker Eiji Miyoshi 7. Development of lectin microarray for glycan profiling and its application to disease-related biomarker development Jun Hirabayashi and Atsushi Kuno 8. Cellular glycomics and versatile applications of lectin microarray Jul Hirabayashi and Hiroaki Tateno 9. Carbohydrate-binding protein array Richard Cummings and David Smith 10. Detection of weak binding sugar activity using membrane-based carbohydrates Kazuo Yamamoto 11. Binding to synthetic glycopeptides Anne Lepannen and Richard Cummings 12. Glycan array and Malectin Ten Feizi 13. Imaging mass spectrometry Naoko Goto-Inoue Section II. Chemical Glycobiology 14. NMR Yoshiki Yamaguchi 15. Self/non-self recognition Koichi Fukase 16. Multivalent ligand for CD22 Mary O'Reilly and Jim Paulson 17. Intramolecular interaction David Live 18. Bacterial furanosides Todd Lowary 19. 1,2-Cis glycoside of amino sugar. Shino Manabe 20. Aminoglycoside antibiotics Timor Baasov 21. Solid phase carbohydrate synthesis Peter Seeberger, Steffen Eller, Markus Weishaupt 22. Novel synthesis of functional mucin glycopeptides containing both N- and O-glycans Shin-itiro Nishimura 23. Chemoenzymatic synthesis of N-glycan Wei Huang 24. Sialyl glycopeptides synthesis Yosuhiro Kajihara 25. Synthesis of sialosides Makoto Kiso 26. Metabolic glycosylation Jennifer Kohler 27. Targeting tumors using homing peptides Michiko Fukuda ...

List of contents

Section I. Glycomics
1. Mass spectrometric analysis of acidic oligosaccharides
K-H. Khoo
2. Mass Spectrometric Analysis of mutant mice
Anne Dell
3. Electrospray mass spectrometry including ESI FTICR-MS
Robert Linhardt
4. Mass spectrometric data base for N-glycan and O-glycan
H. Narimatsu
5. Mass spectrometric analysis of cancer-associated N-glycans.
Shinichiro Nishimura
6. Fucosylation as cancer marker
Eiji Miyoshi
7. Development of lectin microarray for glycan profiling and its application to disease-related biomarker development
Jun Hirabayashi and Atsushi Kuno
8. Cellular glycomics and versatile applications of lectin microarray
Jul Hirabayashi and Hiroaki Tateno
9. Carbohydrate-binding protein array
Richard Cummings and David Smith
10. Detection of weak binding sugar activity using membrane-based carbohydrates
Kazuo Yamamoto
11. Binding to synthetic glycopeptides
Anne Lepannen and Richard Cummings
12. Glycan array and Malectin
Ten Feizi
13. Imaging mass spectrometry
Naoko Goto-Inoue
Section II. Chemical Glycobiology
14. NMR
Yoshiki Yamaguchi
15. Self/non-self recognition
Koichi Fukase
16. Multivalent ligand for CD22
Mary O'Reilly and Jim Paulson
17. Intramolecular interaction
David Live
18. Bacterial furanosides
Todd Lowary
19. 1,2-Cis glycoside of amino sugar.
Shino Manabe
20. Aminoglycoside antibiotics
Timor Baasov
21. Solid phase carbohydrate synthesis
Peter Seeberger, Steffen Eller, Markus Weishaupt
22. Novel synthesis of functional mucin glycopeptides containing both N- and O-glycans
Shin-itiro Nishimura
23. Chemoenzymatic synthesis of N-glycan
Wei Huang
24. Sialyl glycopeptides synthesis
Yosuhiro Kajihara
25. Synthesis of sialosides
Makoto Kiso
26. Metabolic glycosylation
Jennifer Kohler
27. Targeting tumors using homing peptides
Michiko Fukuda

Report

"This book is very informative and is novel both in terms of problems discussed and also new methods used for glycobiology. This is also typical for the two subsequent volumes of "Methods in Enzymology" (Vols. 479 and 480), which will be also reviewed in Biochemistry (Moscow). This book will be very useful for glycobiologists and bioorganic chemists as well as for researchers working in molecular biology and biotechnology. It can also be recommended for university students and their teachers as supplemental material for the above-mentioned fields of science." --Biochemistry (Moscow)

Product details

• Authors: Minoru (EDT) Fukuda
• Assisted by: Minoru Fukuda (Editor), Minoru Fukuda (Editor of the series)
• Publisher: Academic Press London
• Languages: English
• Product format: Hardback
• Release: 01.09.2010, delayed
• EAN: 9780123810014
• ISBN: 978-0-12-381001-4
• No. of pages: 350
• Series: Academic Press; Academic Press; Methods in Enzymology
• Subjects: Natural sciences, medicine, IT, technology > Biology > General, dictionaries; SCIENCE / Life Sciences / Biochemistry, biochemistry, CARBOHYDRATES