Glycomics

Klappentext In the past decade, a tremendous progress in understanding the function of carbohydrates or glycans took place. This progress also starts showing the promise of drug development based on the function of carbohydrates. This critical progress largely owes a development of new methodology to determine a role of a carbohydrate and then develop a method to interfere such biological process, mostly taking a form of protein-carbohydrate interaction. In the current three volumes of Methods in Enzymology focusing on glycomics, readers will appreciate how such discoveries were made and how such methods can be applied for readers¿ own research efforts. Each chapter has been designed so that enough scientific background will be given in each chapter for further development of methods by readers themselves. The books thus should be useful for all levels of scientists starting from the last years of colleges, graduate students, postdoctoral fellows to professors and to all levels of scientists in research institutes including industry. The editor is highly hopeful and confident that these volumes of Methods in Enzymology will contribute to another surge in determining the structure and function of glycans and developing new drugs based on carbohydrate functions. Zusammenfassung A collection focusing on glycomics. It lets readers appreciate how such discoveries were made and how such methods can be applied for readers' own research efforts. It is suitable for different levels of scientists starting from the last years of colleges! graduate students! postdoctoral fellows to professors. Inhaltsverzeichnis Section I. Proteoglycans and Sulfotransferases 1. 3-O-sulfotransferases Nicholas Scworak 2. Proteoglycan and signal transduction Michael Simon 3. Glypican function Xinhua Lin 4. Glycomics profiling of heparan sulfate Jeremy Turnbull Section II. Infection and lectin 5. Recognition of carbohydrates by natural killer T cells Mitch Kronenberg 6. Microbial glycoconjugates in innate immunology Antonio Molinaro 7. Schistosome glycolipids and their role in innate immunity Irma Van Die and Rudolf Guyer 8. Carbohydrate-specific signaling through the DC-SIGN Teunis Geijtenbeek 9. Natural and engineered carbohydrate-recognition domains for targeted glycoproteomic analysis of cell surface glycosylation and identification of ligands for glycan-binding receptors Kurt Drickamer 10. MRH-domain containing lectin ERAD Nobuko Hirosawa 11. Galectin and the control of immune tolerance Gabriel Rabinovich 12. Galectin and cell signaling Michel Demetriou 13. Galectin-1 and HIV infection Sachiko Sato Secion III. Drosophila 14. Drosophila N- and O-glycans Michael Tiemeyer 15. MRH-domain containing lectin ERAD Nobuko Hirosawa 16. Drosophila proteoglycans Shoko Nishihara Section IV. Notch Signaling 17. O-GlcNAc modification of EGF domain of notch Tetsuya Okajima 18. Regulation of Notch signaling via O-glycosylation Jafar-Nejad Hamed Section V. New Development 19. O-fucosylation of Thrombospondin type 1 repeats Robert Haltiwanger 20. Unique glycans attached to unique glycoproteins Michael Pierce 21. Autoantibodies against carbohydrates Michel Hollingsworth 22. GPRH is critical for Golgi apparatus function Yusuke Maeda and Taroh Kinoshita 23. Genome-wide RNAi screen for N-glycosylation loci Weston B Struwe 24. Fucosyl glycans that bind to Helicobacter pylori Tatsuo Miyazaki and Katsumi Ajisaka 25. Seven-pass transmembrane glycoprotein, a glucose-responding receptor Yoshio Hirabayashi ...

List of contents

Section I. Proteoglycans and Sulfotransferases
1. 3-O-sulfotransferases
Nicholas Scworak
2. Proteoglycan and signal transduction
Michael Simon
3. Glypican function
Xinhua Lin
4. Glycomics profiling of heparan sulfate
Jeremy Turnbull
Section II. Infection and lectin
5. Recognition of carbohydrates by natural killer T cells
Mitch Kronenberg
6. Microbial glycoconjugates in innate immunology
Antonio Molinaro
7. Schistosome glycolipids and their role in innate immunity
Irma Van Die and Rudolf Guyer
8. Carbohydrate-specific signaling through the DC-SIGN
Teunis Geijtenbeek
9. Natural and engineered carbohydrate-recognition domains for targeted glycoproteomic analysis of cell surface glycosylation and identification of ligands for glycan-binding receptors
Kurt Drickamer
10. MRH-domain containing lectin ERAD
Nobuko Hirosawa
11. Galectin and the control of immune tolerance
Gabriel Rabinovich
12. Galectin and cell signaling
Michel Demetriou
13. Galectin-1 and HIV infection
Sachiko Sato
Secion III. Drosophila
14. Drosophila N- and O-glycans
Michael Tiemeyer
15. MRH-domain containing lectin ERAD
Nobuko Hirosawa
16. Drosophila proteoglycans
Shoko Nishihara
Section IV. Notch Signaling
17. O-GlcNAc modification of EGF domain of notch
Tetsuya Okajima
18. Regulation of Notch signaling via O-glycosylation
Jafar-Nejad Hamed
Section V. New Development
19. O-fucosylation of Thrombospondin type 1 repeats
Robert Haltiwanger
20. Unique glycans attached to unique glycoproteins
Michael Pierce
21. Autoantibodies against carbohydrates
Michel Hollingsworth
22. GPRH is critical for Golgi apparatus function
Yusuke Maeda and Taroh Kinoshita
23. Genome-wide RNAi screen for N-glycosylation loci
Weston B Struwe
24. Fucosyl glycans that bind to Helicobacter pylori
Tatsuo Miyazaki and Katsumi Ajisaka
25. Seven-pass transmembrane glycoprotein, a glucose-responding receptor
Yoshio Hirabayashi

Report

"Like the previous Vols. 478 and 479, the book is very informative, and it is novel both in terms of problems discussed and also new methods used for glycobiology. This book will be very useful to a wide variety of readers from graduate students, researchers in academia, in industry, and to those who teach glycobiology and glycosciences at various levels." --Biochemistry (Moscow)

Product details

• Authors: Minoru (EDT) Fukuda
• Assisted by: Minoru Fukuda (Editor)
• Publisher: Academic Press London
• Languages: English
• Product format: Hardback
• Release: 01.09.2010, delayed
• EAN: 9780123809995
• ISBN: 978-0-12-380999-5
• No. of pages: 350
• Series: Academic Press; Academic Press; Methods in Enzymology
• Subjects: Natural sciences, medicine, IT, technology > Biology > General, dictionaries; SCIENCE / Life Sciences / Biochemistry, biochemistry, CARBOHYDRATES