Glycomics

Klappentext In the past decade, a tremendous progress in understanding the function of carbohydrates or glycans took place. This progress also starts showing the promise of drug development based on the function of carbohydrates. This critical progress largely owes a development of new methodology to determine a role of a carbohydrate and then develop a method to interfere such biological process, mostly taking a form of protein-carbohydrate interaction. In the current three volumes of Methods in Enzymology focusing on glycomics, readers will appreciate how such discoveries were made and how such methods can be applied for readers¿ own research efforts. Each chapter has been designed so that enough scientific background will be given in each chapter for further development of methods by readers themselves. The books thus should be useful for all levels of scientists starting from the last years of colleges, graduate students, postdoctoral fellows to professors and to all levels of scientists in research institutes including industry. The editor is highly hopeful and confident that these volumes of Methods in Enzymology will contribute to another surge in determining the structure and function of glycans and developing new drugs based on carbohydrate functions. Zusammenfassung A collection focusing on glycomics. It lets readers appreciate how such discoveries were made and how such methods can be applied for readers' own research efforts. It is suitable for different levels of scientists starting from the last years of colleges! graduate students! postdoctoral fellows to professors. Inhaltsverzeichnis Section I. Stem Cell 1. ?4-galactosyltransferase V in growth regulation Jianxin Gu 2. Roles of Polysialic acid in neural stem cells Kiyohiko Angata 3. Chondroitin sulfate in neural stem cells Andreas Faissner 4. Transcription in Stem Cell Kelly Moremen 5. Directing stem cell trafficking through GPS Robert. Sackstein Section II. Gene knockout and mutant mice 6. Cosmc-chaperone Richard Cummings Ju 7. Core 3 O-glycan Lijuan Xia 8. Core3 glycan as tumor suppressor Lee Fukuda 9. Core 4 O-glycan Jamey Marth, Minoru Fukuda 10. b3GlcNAcT2, a major polylacosamine synthase Akira. Togayachi and Hisashi Narimatsu 11. GalNAcT-1 Mari Tenno. Jamey Marth 12. GlcNAcT-IVa-Diabetes Kazuaki Ohtsubo and Jamey Marth 13. Ashwell receptor Prabhijt. Grewal and Jamey Marth 14. Roles ofGlcNAc-6-O-sulfotransferases in lymphoid and non-lymphoid tissues Hiroto Kawashima 15. ?lcNAcT3-core 2GlCNAcT1-selectin ligand Junya. Mitoma and Minoru Fukuda 16. ManII-ManIIX Michiko Fukuda 17. Histochemical analysis carbohydrate antigens in inflammation Motohiro Kobayashi and Jun Nakayama Section III. Alpha-Dystroglycan and tumor 18. Genetic defect in muscular dystrophy Paul Martin 19. POMT1 knockout Sabine Strahl and Jesus Cruces 20. POMGnT1 Mutation in human Tamao and Endo 21. POMGnT1 Knockout mice Huaiyu Hu 22. Large mutation and Large 2. Jane. Hewitt 23. a-dystroglycan glycans as tumor suppressor Xingfeng Bao and Minoru Fukuda 24. Tumor formation assay Shingo Hatakeyama and Chikara Ohyama ...

List of contents

Section I. Stem Cell
1. ?1,4-galactosyltransferase V in growth regulation
Jianxin Gu
2. Roles of Polysialic acid in neural stem cells
Kiyohiko Angata
3. Chondroitin sulfate in neural stem cells
Andreas Faissner
4. Transcription in Stem Cell
Kelly Moremen
5. Directing stem cell trafficking through GPS
Robert. Sackstein
Section II. Gene knockout and mutant mice
6. Cosmc-chaperone
Richard Cummings Ju
7. Core 3 O-glycan
Lijuan Xia
8. Core3 glycan as tumor suppressor
Lee Fukuda
9. Core 4 O-glycan
Jamey Marth, Minoru Fukuda
10. b3GlcNAcT2, a major polylacosamine synthase
Akira. Togayachi and Hisashi Narimatsu
11. GalNAcT-1
Mari Tenno. Jamey Marth
12. GlcNAcT-IVa-Diabetes
Kazuaki Ohtsubo and Jamey Marth
13. Ashwell receptor
Prabhijt. Grewal and Jamey Marth
14. Roles ofGlcNAc-6-O-sulfotransferases in lymphoid and non-lymphoid tissues Hiroto Kawashima
15. ?3GlcNAcT3-core 2GlCNAcT1-selectin ligand
Junya. Mitoma and Minoru Fukuda
16. ManII-ManIIX
Michiko Fukuda
17. Histochemical analysis carbohydrate antigens in inflammation
Motohiro Kobayashi and Jun Nakayama
Section III. Alpha-Dystroglycan and tumor
18. Genetic defect in muscular dystrophy
Paul Martin
19. POMT1 knockout
Sabine Strahl and Jesus Cruces
20. POMGnT1 Mutation in human
Tamao and Endo
21. POMGnT1 Knockout mice
Huaiyu Hu
22. Large mutation and Large 2.
Jane. Hewitt
23. a-dystroglycan glycans as tumor suppressor
Xingfeng Bao and Minoru Fukuda
24. Tumor formation assay
Shingo Hatakeyama and Chikara Ohyama

Report

"The book is very informative, and it is novel both in terms of problems discussed and also new methods used for glycobiology.This book will be very useful to a wide variety of readers from graduate students, researchers in academia, in industry, and to those who teach glycobiology and glycosciences at various levels." --Biochemistry 2011, Vol. 76, No. 10, p. 1193

"Like the previous Vol. 478, the book is very informative, and is novel both in terms of problems discussed and also new methods used for glycobiology. This book will be very useful to a wide variety of readers from graduate students, researchers in academia, in industry, and to those who teach glycobiology and glycosciences at various levels." --Biochemistry (Moscow)

Product details

• Authors: Minoru (EDT) Fukuda
• Assisted by: Minoru Fukuda (Editor)
• Publisher: Academic Press London
• Languages: English
• Product format: Hardback
• Release: 01.09.2010, delayed
• EAN: 9780123809971
• ISBN: 978-0-12-380997-1
• No. of pages: 350
• Series: Academic Press; Academic Press; Methods in Enzymology
• Subjects: Natural sciences, medicine, IT, technology > Biology > General, dictionaries; SCIENCE / Life Sciences / Biochemistry, biochemistry, CARBOHYDRATES