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Chemokines are hormone-like signaling molecules secreted by cells to signal infection and guide the immune response. Following a decade of basic chemokine research, the pharmaceutical industry has now begun to exploit this crucial signaling pathway for the development of innovative drugs against AIDS, cancer, neural and autoimmune diseases. Here is the first reference focusing on these novel drug development opportunities.Opening with a general introduction on chemokine function and chemokine receptor biology, the second part covers the known implications of these signaling molecules in human diseases, such as cancer, neural disorders, and viral infection, including AIDS. The third part systematically surveys current drug development efforts at targeting individual chemokine receptors, as well as other chemokine interaction partners, including up-to-date reports from the pharmaceutical industry.
List of contents
FUNDAMENTALS OF CHEMOKINES AND CHEMOKINE RECEPTORSStructural Aspects of Chemokines, and their Interactionss with Receptors and GAGsStructural Insights for Homology Modeling of Chemokine ReceptorsSignaling Events Involved in Chemokine-Directed T Lymphocyte MigrationThe Atypical Chemokine ReceptorsTargeting Chemokine Receptor Dimers: Are there Two (or More) to Tango?CHEMOKINE RECEPTORS IN DISEASEChemokine Receptors in Inlammatory DiseasesChemokines and their Receptors in Central Nervous System DiseaseChemokines and Cancer MetastasisConstitutively Active Viral Chemokine Receptors: Tools for Immune Subversion and PathogenesisTARGETING CHEMOKINE RECEPTORSCCR5 Antagonists in HIVCXCR4 as therapeutic targetLow-Molecular Weight CXCR2 Antagonists as Promising TherapeuticsTherapeutic Targeting of the CXCR3 ReceptorsTargeting CCR1Targeting CCR3Chemokine-Binding Proteins as Therapeutics
About the author
The editors are based at the Amsterdam Center for Drug Research, a cross-disciplinary center in the Dutch academic system, but with numerous ties to pharmaceutical companies.
Summary
Chemokines are hormone-like signaling molecules secreted by cells to signal infection and guide the immune response. Following a decade of basic chemokine research, the pharmaceutical industry has now begun to exploit this crucial signaling pathway for the development of innovative drugs against AIDS, cancer, neural and autoimmune diseases. Here is the first reference focusing on these novel drug development opportunities.
Opening with a general introduction on chemokine function and chemokine receptor biology, the second part covers the known implications of these signaling molecules in human diseases, such as cancer, neural disorders, and viral infection, including AIDS. The third part systematically surveys current drug development efforts at targeting individual chemokine receptors, as well as other chemokine interaction partners, including up-to-date reports from the pharmaceutical industry.
Report
"This is an excellent introduction to the topic of chemokine receptors as drug targets. Authors from both academia and the pharmaceutical industry provide updates on the progress in the research on chemokines and their receptors leading to a new approach of drug discovery to target many diseases." (Doody s, 14 October 2011)
"This book covers chemokine receptors more thoroughly than any other that I have seen to date. This is an ideal text for researchers seeking to understand the full spectrum of chemokine receptor biology, recent and historical progress towards receptor inhibitors, and insights and perspectives for future research directions." (ChemMedChem, 1 August 2011)
