Dna Deamination and the Immune System: Aid in Health and Disease - Aid in Health and Disease

Klappentext This monograph covers current understanding of the role of activation induced cytidine deaminase (AID) in the generation of antibody response to antigenic challenge. Since the discovery of AID and the genetic demonstration of its role in somatic hypermutation and class switch recombination of antibody genes, much has been learned about the biochemistry of this enzyme. However, some key questions (How does this enzyme get to the antibody locus leaving the rest of the genome intact? Why are DNA repair pathways which normally repair deamination events co-opted into actually fixing mutations into the genome?) remain hotly contested. These questions will be addressed in this monograph from various perspectives. Being leading experts in their respective fields, the contributors of this highly valued monograph summarize current research in the field of AID and put forth hypotheses in order to provide a platform for future experiments. Zusammenfassung Covers the understanding of the role of activation-induced cytidine deaminase (AID) in the generation of antibody response to antigenic challenge. Inhaltsverzeichnis Switch Regions! Chromatin Accessibility and AID Targeting; Cis-Regulatory Elements that Target AID to Immunoglobulin Loci; Partners in Diversity: The Search for AID Co-Factors; Resolution of AID Lesions in Class Switch Recombination; Error-Prone and Error-Free Resolution of AID Lesions in SHM; Regulatory Mechanisms of AID Function; AID in Immunodeficiency and Cancer; AID in Aging and in Autoimmune Disease.

Product details

• Authors: Sebastian Diaz Fugmann, Nina (Rockefeller Univ Papavasiliou, Marilyn Diaz Et Al Sebastian Fugmann
• Assisted by: Marilyn Diaz (Editor), Marilyn (National Inst Of Health Diaz (Editor), Sebastian Fugmann (Editor), Sebastian (National Inst Of Health Fugmann (Editor), Nina Papavasiliou (Editor), Nina (Rockefeller Univ Papavasiliou (Editor)
• Publisher: Imperial College Press
• Languages: English
• Product format: Hardback
• Released: 27.10.2010
• EAN: 9781848165922
• ISBN: 978-1-84816-592-2
• No. of pages: 232
• Series: Molecular Medicine and Medicin; Molecular Medicine and Medicinal Chemistry
• Subject: Natural sciences, medicine, IT, technology > Biology > Miscellaneous