Diverse Effects of Hypoxia on Tumor Progression

Hypoxia, defined as reduced oxygen tension, is a common physiological phenomenon in both normal embryonic development and malignancy progression. Although severe hypoxia is generally toxic for both normal tissue and tumors, neoplastic cells gradually adapt to prolonged hypoxia though additional genetic and genomic changes with a net result that hypoxia promotes tumor progression and therapeutic resistance. Hypoxia promotes cancer progression by regulating various aspects of cancer biology, including radiotherapy resistance, metabolism, angiogenesis and invasion/migration

List of contents

The HIF-2?-Driven Pseudo-Hypoxic Phenotype in Tumor Aggressiveness, Differentiation, and Vascularization.- Hypoxia and Hypoxia Inducible Factors in Cancer Stem Cell Maintenance.- Role of Carcinoma-Associated Fibroblasts and Hypoxia in Tumor Progression.- The Role of Hypoxia Regulated microRNAs in Cancer.- Oxygen Sensing: A Common Crossroad in Cancer and Neurodegeneration.- Hypoxia-Inducible Factors as Essential Regulators of Inflammation.- Hypoxia and Metastasis in Breast Cancer.

Summary

Hypoxia, defined as reduced oxygen tension, is a common physiological phenomenon in both normal embryonic development and malignancy progression. Although severe hypoxia is generally toxic for both normal tissue and tumors, neoplastic cells gradually adapt to prolonged hypoxia though additional genetic and genomic changes with a net result that hypoxia promotes tumor progression and therapeutic resistance. Hypoxia promotes cancer progression by regulating various aspects of cancer biology, including radiotherapy resistance, metabolism, angiogenesis and invasion/migration

Product details

• Assisted by: Celeste Simon (Editor), M Celeste Simon (Editor), Celeste M. Simon (Editor), M. Celeste Simon (Editor)
• Publisher: Springer, Berlin
• Languages: English
• Product format: Hardback
• Released: 01.09.2010
• EAN: 9783642133282
• ISBN: 978-3-642-13328-2
• No. of pages: 146
• Weight: 378 g
• Illustrations: X, 146 p.
• Series: Current Topics in Microbiology and Immunology; Current Topics in Microbiology and Immunology
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Non-clinical medicine; Physiologie, B, Entwicklungsbiologie, HUMAN PHYSIOLOGY, METABOLISM, PHYSIOLOGY, Embryology, Biomedical and Life Sciences, Cancer Research, Cellular biology (cytology), Biomedical Research, Cancer Biology, tissue, Hypoxia-Inducible Factors, microRNAs, tumor progression