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Informationen zum Autor Bing Yan received his Ph.D. from Columbia University with Koji Nakanishi in 1990. He is a faculty member at the Department of Chemical Biology and Therapeutics at St. Jude Children’s Research Hospital in Memphis, Tennessee, and an adjunct professor at Shandong University. Bin Zhang received his Ph.D. from the Institute of Inorganic and Analytical Chemistry and Radiochemistry at Saarland University (Germany) with Professor Doctor Horst P. Beck in 2003. He is an associate professor of analytical chemistry in the School of Chemistry and Chemical Engineering at Shandong University, China. Klappentext Written by leaders in the field! Analytical Methods in Combinatorial Chemistry is the first comprehensive review of analytical methods in this field! with a focus on combinatorial drug discovery. The second edition updates the first with close to 50% new material and a detailed discussion of new developments in analytical methods! technologies! and applications in combinatorial chemistry in the past three years. The book also includes new chapters on high-throughput purification and the application of combinatorial chemistry in materials science and catalyst discovery. It focuses on new drug candidates and drugs developed through combinatorial chemistry. Zusammenfassung Reflecting the growth in the field and the heightened focus on select areas, this book focuses on high-throughput purification methods. It discusses properties of solid-phase samples, analytical studies targeted to understand these properties, and resin swelling. It provides an analysis of the developments in analytical methods and technologies. Inhaltsverzeichnis Analytical issues in combinatorial chemistry. An examination of the analytical sample resin support. Solid-phase reaction optimization using FTIR. Reaction optimization using MS and NMR methods. Reaction optimization using spectrophotometric and other methods. Quality control of combinatorial libraries. High-throughput purification. Final Thoughts and Future Perspectives. ...
