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Informationen zum Autor Katharina Dittmar de la Cruz holds both a Ph.D. in Molecular Parisitology and Entomology and a doctorate in Veterinary Medicine, both from the University of Leipzig, Germany. An expert in phylogenetics, molecular evolution, and bioinformatics, she has recently turned her attention toward examining the implications of evolutionary forces on drug design. Dr. Dittmar is an Assistant Professor at the SUNY University at Buffalo. David Liberles earned his Ph.D. in Chemistry at the California Institute of Technology working on the biochemsitry of nucleic acids. Subsequently, he has developed significant expertise in bioinformatics, computational biology and functional genomics. His broad experience includes a professorship at the Stockholm Bioinformatics Center and consultancies with Novo Nordisk and other private research and diagnostic companies. Currently he is Vice-Director of the University of Wyoming Bioinformatics Center and Assistant Professor of Molecular Biology. Klappentext Gene duplication has long been believed to have played a major role in the rise of biological novelty through evolution of new function and gene expression patterns. The first book to examine gene duplication across all levels of biological organization, Evolution after Gene Duplication presents a comprehensive picture of the mechanistic process by which gene duplication may have played a role in generating biodiversity. Key Features: Explores comparative genomics, genome evolution studies and analysis of multi-gene families such as Hox , globins, olfactory receptors and MHC (immune system) A complete post-genome treatment of the topic originally covered by Ohno's 1970 classic, this volume extends coverage to include the fate of associated regulatory pathways Taps the significant increase in multi-gene family data that has resulted from comparative genomics Comprehensive coverage that includes opposing theoretical viewpoints, comparative genomics data, theoretical and empirical evidence and the role of bioinformatics in the study of gene duplication This up-to-date overview of theory and mathematical models along with practical examples is suitable for scientists across various levels of biology as well as instructors and graduate students. Zusammenfassung * Pertinent to anyone involved in comparative genomics, genome evolution studies or analysis of any of the multi-gene families such as Hox, globins, olfactory receptors, MHC (immune system), etc. Inhaltsverzeichnis Contributors vii Preface xi 1 Understanding Gene Duplication Through Biochemistry and Population Genetics 1 David A. Liberles, Grigory Kolesov, and Katharina Dittmar 2 Functional Divergence of Duplicated Genes 23 Takashi Makino, David G. Knowles, and Aoife McLysaght 3 Duplicate Retention After Small- and Large-Scale Duplications 31 Steven Maere and Yves Van de Peer 4 Gene Dosage and Duplication 57 Fyodor A. Kondrashov 5 Myths and Realities of Gene Duplication 77 Austin L. Hughes and Robert Friedman 6 Evolution After and Before Gene Duplication? 105 Tobias Sikosek and Erich Bornberg-Bauer 7 Protein Products of Tandem Gene Duplication: A Structural View 133 William R. Taylor and Michael I. Sadowski 8 Statistical Methods for Detecting Functional Divergence of Gene Families 163 Xun Gu 9 Mapping Gene Gains and Losses Among Metazoan Full Genomes Using an Integrated Phylogenetic Framework 173 Athanasia C. Tzika, Raphäel Helaers, and Michel C. Milinkovitch 10 Reconciling Phylogenetic Trees 185 Oliver Eulenstein, Snehalata Huzurbazar, and David A. Liberles 11 On the Energy and Material Cost of Gene Duplication 207 Andreas Wagner 12 Fate of a Duplicate in a Network Context 2...
