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Dramatic advances have been made in recent years in the field of redox enzymology which has resulted in an increase of research activities. This volume will cover the recent milestone developments in this field by leading experts, uniting theory and experiment, and selecting contributions to illustrate important aspects of the mechanisms of electron and radical transfer in proteins.
Features:
A demonstration of the key principles controlling biological redox reactions;
Experimental studies of `simple' soluble systems in various enzyme familiies to illustrate concepts in the control of electron transfer reactions;
Detail of advances made in membrane electron transfer through structural descriptions of key membrane-embedded proteins;
Appeal to those interested in the design and use of redox enzymes, from academics to industrialists.
List of contents
Electron Transfer in Natural Proteins Theory and Design.- Flavin Electron Transfer Proteins.- Methanol Dehydrogenase, a PQQ-Containing Quinoprotein Dehydrogenase.- Methylamine Dehydrogenase Structure and Function of Electron Transfer Complexes.- Trimethylamine Dehydrogenase and Electron Transferring Flavoprotein.- Amine Oxidases and Galactose Oxidase.- Electron Transfer and Radical Forming Reactions of Methane Monooxygenase.- Flavocytochrome b2.- Flavocytochrome P450 BM3 Substrate Selectivity and Electron Transfer in a Model Cytochrome P450.- Peroxidase-Catalyzed Oxidation of Ascorbate Structural, Spectroscopic and Mechanistic Correlations in Ascorbate Peroxidase.- Adenosylcobalamin-Dependent Enzymes.- Ribonucleotide Reductase A Virtual Playground for Electron Transfer Reactions.- Molybdenum Enzymes.- Nickel Containing CO Dehydrogenases and Hydrogenases.- Cytochrome cd1 Nitrite Reductase Structure Raises Interesting Mechanistic Questions.- Mitochondrial Cytochrome bc1 Complex.- Bovine Heart Cytochrome c Oxidase.- Reaction Centres of Purple Bacteria.
Summary
Experimental studies of `simple' soluble systems in various enzyme familiies to illustrate concepts in the control of electron transfer reactions; Detail of advances made in membrane electron transfer through structural descriptions of key membrane-embedded proteins;
