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Informationen zum Autor Dr. Ujjwal Maulik is Professor of Computer Science and Engineering at Jadavpur University (India). He is the editor or author of five books and coauthor of more than 150 articles. Dr. Maulik is a Senior Member of IEEE and also a Humboldt Fellow. Dr. Sanghamitra Bandyopadhyay is Professor at the Indian Statistical Institute. She is the editor or author of six books and coauthor of more than 180 articles. Dr. Bandyopadhyay is a Senior Member of IEEE and also a Humboldt Fellow. Dr. Jason T. L. Wang is a Professor and Director of the Data and Knowledge Engineering Lab at the New Jersey Institute of Technology. He is the editor or author of six books and Executive Editor of the World Scientific Book Series on Science, Engineering, and Biology Informatics. Klappentext An invaluable tool in Bioinformatics, this unique volume provides both theoretical and experimental results, and describes basic principles of computational intelligence and pattern analysis while deepening the reader's understanding of the ways in which these principles can be used for analyzing biological data in an efficient manner.This book synthesizes current research in the integration of computational intelligence and pattern analysis techniques, either individually or in a hybridized manner. The purpose is to analyze biological data and enable extraction of more meaningful information and insight from it. Biological data for analysis include sequence data, secondary and tertiary structure data, and microarray data. These data types are complex and advanced methods are required, including the use of domain-specific knowledge for reducing search space, dealing with uncertainty, partial truth and imprecision, efficient linear and/or sub-linear scalability, incremental approaches to knowledge discovery, and increased level and intelligence of interactivity with human experts and decision makers* Chapters authored by leading researchers in CI in biology informatics.* Covers highly relevant topics: rational drug design; analysis of microRNAs and their involvement in human diseases.* Supplementary material included: program code and relevant data sets correspond to chapters. Zusammenfassung An invaluable tool in Bioinformatics, this unique volume provides both theoretical and experimental results, and describes basic principles of computational intelligence and pattern analysis while deepening the reader's understanding of the ways in which these principles can be used for analyzing biological data in an efficient manner. Inhaltsverzeichnis Preface. Contributors. PART 1 INTRODUCTION. 1 Computational Intelligence: Foundations, Perspectives, and Recent Trends ( Swagatam Das, Ajith Abraham, and B. K. Panigrahi). 2 Fundamentals of Pattern Analysis: A Brief Overview ( Basabi Chakraborty ). 3 Biological Informatics: Data, Tools, and Applications ( Kevin Byron, Miguel Cervantes-Cervantes, and Jason T. L. Wang ). PART II SEQUENCE ANALYSIS. 4 Promoter Recognition Using Neural Network Approaches ( T. Sobha Rani, S. Durga Bhavani, and S. Bapi Raju ). 5 Predicting microRNA Prostate Cancer Target Genes ( Francesco Masulli, Stefano Rovetta, and Giuseppe Russo ). PART III STRUCTURE ANALYSIS. 6 Structural Search in RNA Motif Databases ( Dongrong Wen and Jason T. L. Wang ). 7 Kernels on Protein Structures ( Sourangshu Bhattacharya, Chiranjib Bhattacharyya, and Nagasuma R. Chandra ). 8 Characterization of Conformational Patterns in Active and Inactive Forms of Kinases using Protein Blocks Approach ( G. Agarwal, D. C. Dinesh, N. Srinivasan, and Alexandre G. de Brevern ). 9 Kernel Function Applications in Cheminformatics ( Aaron Smalter and Jun Huan ). 10 In Silico Drug Design Using a Computational Intellig...
