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The book covers major advances made in cellular bioenergetics, a central topic in biological and medical research. The chapters, contributed by authors representing major groups working in the field, extend from the latest advancements in X-ray crystallographic analysis of the atomic structure of energy transfer membrane proteins and analysis of their mechanism of action, to perspectives on the implication of their genetic and phenotypic defects in human diseases. The book, intended for researchers, clinicians and students aims at providing an up-to-date appraisal of this rapidly developing biomedical field.
The book consists of thirty-one chapters contributed by leading experts in the field of cellular bioenergetics. Three sections cover the X-ray crystallographic analysis, mutational analysis and mechanism of action of mitochondrial and prokaryotic respiratory enzymes, ATP synthase and mitochondrial carriers. One section deals with genetics and biogenesis of mitochondria. The fourth section covers genetic and phenotypic defects in mitochondrial energy transfer proteins associated with inborn and/or degenerative human diseases and aging.
List of contents
1. The Mitochondrial and Bacterial Respiratory Chains: From MacMunn and Keilin to Current Concepts; P. Nicholls. 2. The Mitochondrial Enzymes of Oxidative Phosphorylation; Y. Hatefi. 3. Proton Pumps of Respiratory Chain Enzymes; S. Papa, et al. 4. Uncoupling of Respiration and Phosphorylation; V.P. Skulachev. 5. Crystallization, Structure, and Possible Mechanism of Action of Cytochrome c Oxidase from the Soil Bacterium Paracoccus denitrificans ; M. Hartmut, et al. 6. The Structure of Crystalline Bovine Heart Cytochrome c Oxidase; S. Yoshikawa, et al. 7. Electron and Proton Transfer in Heme-Copper Oxidases; Yuejun Zhen, et al. 8. Mechanism of Proton-Motive Activity of Heme-Copper Oxidases; P.R. Rich. 9. Oxygen Reduction and Proton Translocation by the Heme-Copper Oxidases; M. Wilström, et al. 10. Transient Spectroscopy of the Reaction between Cytochrome c Oxidase and Nitric Oxide: A New Hypothesis on the Mechanism of Inhibition and Oxygen Competition; A. Giuffrè, et al. 11. Energy Transduction in Mitochondrial Respiration by the Proton-Motive Q-Cycle Mechanism of the Cytochrome bc 1 Complex; B.L. Trumpower. 12. The Crystal Structure of Mitochondrial Cytochrome bc 1 Complex; Chang-An Yu, et al. 13. Structural Aspects of the Cytochrome bc 1 Complex; T.A. Link. 14. Structure, Function, and Biogenesis of Respiratory Complex I; U. Schulte, H. Weiss. 15. Structure of F 1 -ATPase and the Mechanism of ATP-Synthesis Hydrolysis; M.A. Bianchet, et al. 16. Mechanism of ATP Synthesis by Mitochondrial ATP Synthase; Abdul-Kader Souid, H.S. Penefsky. 17. Mutational Analysis of ATP Synthase: An Approach to Catalysis and Energy Coupling; M. Futai, H. Omote. 18. Analysis of the Nucleotide Binding Sites of ATP Synthase and Consequences for the Catalytic Mechanism; J.A. Berden, A.F. Hartog. 19. Coupling Structures and Mechanisms in the Stalk of the Bovine Mitochondrial F 0 F 1 -ATP Synthase; S. Papa, et al. 20. The Mitochondrial Carrier Protein Family; F. Palmieri, B. van Ommen. 21. Structure and Evolution of the Metazoan Mitochondrial Genome; C. Saccone. 22. Nuclear Transcription Factors in Cytochrome c and Cytochrome Oxidase Expression; R.C. Scarpulla. 23. Suppressor Genetics of the Mitochondrial Energy Transducing System: The Cytochrome bc 1 Complex; J.-P. di Rago, P.P. Slonimski. 24. Tissue-Specific Expression of Cytochrom c Oxidase Isoforms and role in Nonshivering Thermogenesis; B. Kadenbach, et al. 25. Mitochondrial DNA Mutations and Nuclear Mitochondrial Interactions in Human Disease; H. Cock, et al. 26. Strategy toward Gene Therapy of Mitochondrial DNA Disorders; Peter Seibel, et al. 27. The F 0 F 1 -ATP Synthase in Cell Proliferation and Aging; F. Guerrieri. 28. Age-Linked Changes in the Genotype and Phenotype of Mitochondria; M.N. Gadaleta, et al. 29. Nucleus-Driven Lesions of mtDNA and Disorders of Nucleus-Encoded Energy Genes; M. Zeviani, et al. 30. Aging and Degenerative Diseases: A Mitochondrial Paradigm; D.C. Wallace. 31. Perspectives on the Permeability Transition Pore, a Mitochondrial Channel Involved in Cell Death; P. Bernadi.
