The Renin-Angiotensin System: Current Research Progress in The Pancreas - The RAS in the Pancreas

The human pancreas has vital roles in the regulation of glucose homeostasis and digestion and its dysfunction leads to pancreatic disease as diabetes and pancreatitis. Recent researches have highlighted the novel roles of a local renin-angiotensin system (RAS) in the pancreas and its clinical relevances; its inapprporiate activation leads to pancreatic endocrine and exocrine disease, notably type 2 diabetes. As such, manipulation of the overactive RAS may improve pancreatic islet cell function, cell mass and insulin sensitivity, as well as enhancing the growth and differentiation of pancreatic stem cells. Blockade of the RAS may be protective against pancreatitis and pancreatic cancer. The research outcome of current progress on the RAS in the pancreas should provide an alternative approach to preventing and treating, as well as curing pancreatic disease. This book discusses the progress of research on the renin-angiotensin system in the pancreas from the science to the bedside, providing a timely review of this expanding area. It consists of ten interrelated chapters covering subjects as: -Structure, physiology and disease of the pancreas-Biochemistry and physiology of the pancreatic renin-angiotensin system-RAS in diabetes, stem cells and pancreatitisThis book is of special value to basic and clinical scientists, clinicians, graduate students, as well as novices in this field.

List of contents

The Pancreas.- Overview of the Pancreas.- Physiology of the Pancreas.- Common Pancreatic Disease.- The Renin-Angiotensin System (RAS).- Circulating RAS.- Local RAS.- Pancreatic RAS.- Research Progress Of The Ras In Pancreas.- Basic Techniques for Pancreatic Research.- Current Research of the RAS in Diabetes Mellitus.- Current Research Concerning the RAS in Pancreatic Stem Cells.- Current Research of the RAS in Pancreatitis and Pancreatic Cancer.

Summary

Highlighting the role local renin-angiotensin systems (RAS) play in pancreatic disease, this review presents the latest research advances in the field. These findings suggest both preventative measures and treatment for pancreatic disease.

Product details

• Authors: Po Sing Leung
• Publisher: Springer Netherlands
• Languages: English
• Product format: Hardback
• Released: 06.10.2010
• EAN: 9789048190591
• ISBN: 978-90-481-9059-1
• No. of pages: 208
• Dimensions: 168 mm x 18 mm x 241 mm
• Weight: 490 g
• Illustrations: XVI, 208 p.
• Series: Advances in Experimental Medicine and Biology; Advances in Experimental Medic; Advances in Experimental Medicine and Biology
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Non-clinical medicine; Biologie, Diabetes, Physiologie, Bauchspeicheldrüse, Heilkunde, Medizin, Gastroenterologie, B, Zuckerkrankheit, Diabetes Mellitus, PANKREAS, Medicine, Krankheiten und Störungen, Biologie, Biowissenschaften, Humanmedizin, Life Sciences, HUMAN PHYSIOLOGY, PHYSIOLOGY, INTERNAL MEDICINE, Biowissenschaften, Forschung (medizinisch, psychologisch), Mensch / Physiologie, Mensch / Biologie, Pancreas, Gastroenterology, Biomedical and Life Sciences, Biomedicine, general, Biomedical Research