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Klappentext The Fifth Ir Gene Workshop was held at the Chase-Park Plaza Hotel, St. Louis, MO, August 28-31, 1982; 240 scientists participated in the Workshop. The man uscripts compiled in this book describe the state of the art concerning Ir genes. Although the notion of Ir Genes: Past, Present, and Future has not been ad dressed specifically by each author, the reader is certain to get this flavor from the contributions. In this Preface, we have tried to summarize some of the salient ob servations and discussions from the Workshop. The mUltiple genes of the I region have been defined traditionally by serolog ical analysis of intra-H-2 recombinant mice and the pattern of immune responses to certain antigens developed by these recombinant mice. The application of sev eral new techniques, such as gene cloning and DNA sequencing, production of T and B cell hybridomas, and development of cloned T cell lines has changed this tradition and introduced a new phase into the analysis of the I region, Ia antigens, and Ir genes. Zusammenfassung The Fifth Ir Gene Workshop was held at the Chase-Park Plaza Hotel! St. Louis! MO! August 28-31! 1982; Inhaltsverzeichnis Genetic Organization of I-Region Genes.- Ia Genes, Gene Products, and Determinants.- Murine T Cell-Specific IA Antigens: Helper T Lymphocytes Express a Unique I-A-Encoded Molecule.- Definition of New Ia+ T Cell Subsets.- Antibody and T Cell Recognition of Select Ia Determinants Using the I-A Mutant B6.C-H-2bm12.- Induction of Autoreactive T Cells by Stimulation Across the I-J Subregion.- Enhancement of Murine T Cell I-J Expression by Limited Proteolysis.- Isolation and Analysis of Subpopulations of I-Ab Molecules with Monoclonal Antibodies.- Partial Characterization of 8 Anti-I-J and 3 Anti-Ia Monoclonal Reagents.- Interspecies Cross Reactivity of Monoclonal Anti-I-E Antibodies Specific for Polymorphic Ia Determinants.- Structural Characterization of I-Ab Subsets Using Monoclonal Antibodies.- Factor-Mediated Regulation of the Expression of the H-2 Linked Low Molecular Weight Proteins (LMP).- Quantitation of Ia Antigens on Normal and Leukemic Human Lymphocytes.- Use of Monoclonal Antibodies for Studies of Anti-Ia Receptor Idiotypes.- A Recombinatorial Event Separating the Immune Response Genes for LDH-B and MOPC-173: Implications for a New Model of I Region Gene Organization.- Expression of Ia Antigens and Ir Gene Function During Differentiation of Bone Marrow Derived Macrophage.- The IR-THY-1 Genes: Possible Mechanism of Their Effect.- Complementing Ir-Genes Located in the I-A Subregion and Between the S and D Regions are Required for the Response to TNP-Ficoll.- Chemistry of I-Region Gene Products and DNA Cloning of I-Region Gene Products.- Ia Oligosaccharide Structure and Its Relation to Differential Recognition of Ia.- Structures of the Oligosaccharides of I-Ak Antigen and Localization of Antigenic Sites to A?k and A?k Chains.- Biosynthesis and Genetics of Ia Antigens and Their Associated Invariant Chain.- Biochemical Characterization of the Murine Invariant Polypeptide and a 23,000 Dalton Iad Encoded Polypeptide.- Identification of an Invariant Chain ? of Murine Class II Antigens and Its Relationship to the Invariant Chain ?(Ii).- Molecular Heterogeneity of Ia Antigens: Novel Components and Complexes.- Partial Chemical Characterization of T Lymphocyte I-Region Associated Antigens.- Three Distinct Human Ia Molecules Isolated from a DR5 Homozygous Lymphoblastoid Cell Line.- The Human "Invariant" Chain: Structural Characterization.- Two-Dimensional Gel Analyses of HLA-DR and HLA-DS Molecules.- Partial Structural Characterization of Human SB Antigens.- Two Alpha Chains and Three Beta Chains of Human Ia Antigens.- Isolation and Characterization of I Region Genes from the Major Histocompatibility Complex.- Structure and Expression of the Murine Ia ? Chains.- Extensive Restriction Site Polymorphism Surrounding a Single Copy I-A? Gene.- Ana...
List of contents
Genetic Organization of I-Region Genes.- Chemistry of I-Region Gene Products and DNA Cloning of I-Region Gene Products.- Ir Gene Function: Cellular Site(s) and Mechanism(s) of Action.- The Role of Ia Antigens in Restricted Cell Interactions.- Lessons on Ir Genes Derived from T Cell Clones and T Cell Hybridomas.- Where From Here?.
